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Huovila et al., Trends Biochem Sci 2005
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The recent studies have also begun to elucidate the substrate specificity and the mechanisms that control ADAM mediated shedding events that regulate, for example, growth-factor and Notch signalling, and the processing of the amyloid precursor protein
Dyczynska et al., J Biol Chem 2007
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Our findings expand the role of ADAM proteins in the regulation of Notch signaling
Zolkiewska et al., Cell Mol Life Sci 2008
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ADAM mediated cleavage of Notch represents the first step in regulated intramembrane proteolysis of the receptor, leading to activation of the Notch pathway