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ADRB2 — PRKACB
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Jo et al., Circ Res 2002
:
In the heart, stimulation of
beta2-adrenoceptor (beta2-AR) , a prototypical GPCR,
activates a tightly localized
protein kinase A (PKA) signaling, which regulates substrates at cell surface membranes, bypassing cytosolic target proteins ( eg, phospholamban )
Woo et al., Mol Pharmacol 2009
:
The inefficient G ( i ) signaling with the R, R isomers is not caused by the inability of the R, R isomers to trigger the
protein kinase A (PKA) mediated phosphorylation of the
beta(2)-adrenoceptor , because the R, R isomers also markedly increased phosphorylation of the receptor at serine 262 by PKA