Gene interactions and pathways from curated databases and text-mining

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AKT2 — FAS

Text-mined interactions from Literome

Ivanov et al., J Biol Chem 2002 : Regulation of Fas expression by STAT3 and c-Jun is mediated by phosphatidylinositol 3-kinase-AKT signaling
Takemura et al., Hypertension 2004 : Fas signaling induces Akt activation and upregulation of endothelial nitric oxide synthase expression ... Here, we report that Fas engagement with Fas ligand induced activation of Akt and upregulation of endothelial nitric oxide synthase expression without induction of apoptosis
Uriarte et al., Cell Death Differ 2005 : In T lymphocytes, the role of Akt in regulating Fas/Fas ligand (FasL) mediated apoptotic signaling and death is not clearly understood
Wang et al., Oncogene 2005 (Ovarian Neoplasms) : In contrast, inhibition of FAS activity by the drug C75 resulted in downregulation of phospho-AKT and increased cell death ... Treatment with LY294002 abolished AKT activity and potentiated apoptosis induced by FAS inhibitors cerulenin or C75 only in cells with constitutively active AKT, suggesting that constitutive activation of AKT protects against FAS inhibitor induced cell death ... Furthermore, inhibition of FAS activity by cerulenin or C75 resulted in downregulation of phospho-AKT , which preceded the induction of apoptosis ... Collectively, our findings are consistent with a working model in which AKT activation regulates FAS expression, at least in part, whereas FAS activity modulates AKT activation
Iordanov et al., J Invest Dermatol 2005 (Dermatitis) : Using a variety of inhibitors and blocking antibodies, we demonstrated that : ( i ) apoptosis is required for the generation of the signal ( s ) leading to the activation of EGFR, ERK, and Akt; (ii) the activation of EGFR, ERK, and Akt by FasL is indeed mediated by its bona fide receptor Fas ; ( iii ) the activation of EGFR is essential for the subsequent activation of ERK and Akt ; and ( iv ) apoptotic keratinocytes secrete soluble EGFR ligands ( including amphiregulin ) that are processed from membrane bound proligand forms by metalloproteinase ( s )
Porstmann et al., Oncogene 2005 : Activation of Akt induces synthesis of full-length SREBP-1 and SREBP-2 proteins as well as expression of fatty acid synthase (FAS) , the key regulatory enzyme in lipid biosynthesis ... We also show that Akt leads to the accumulation of nuclear SREBP-1 but not SREBP-2, and that activation of SREBP is required for Akt induced activation of the FAS promoter
Chiang et al., FEBS Lett 2007 (Breast Neoplasms) : The use of pharmacological inhibitors revealed that the modulation of Akt , mTOR and JNK phosphorylation was required for diosgenin induced FAS suppression
Vaillancourt et al., Arthritis Res Ther 2008 (Osteoarthritis) : Our study of signalling pathways revealed that HNE suppressed pro-survival Akt kinase activity but, in contrast, induced Fas/CD95 and p53 expression in chondrocytes
Sinha et al., Int J Dev Neurosci 2009 (Hypothyroidism) : omega3 FAs also restored levels of cerebellar phospho ( p ) -AKT , phospho-extracellular regulated kinase ( p-ERK ) and phospho-c-Jun N-terminal kinase ( p-JNK ), which were altered by hypothyroid insults, without interfering with the expression of TH responsive gene, myelin basic protein (mbp)
Lokeshwar et al., Cancer Res 2010 (Neoplasm Invasiveness...) : 4-MU induced caspase-8, caspase-9, and caspase-3 activation, PARP cleavage, upregulation of Fas-L, Fas , FADD and DR4, and downregulation of bcl-2, phosphorylated bad, bcl-XL, phosphorylated Akt , phosphorylated IKB, phosphorylated ErbB2, and phosphorylated epidermal growth factor receptor
Casado-Zapico et al., J Pineal Res 2011 (Leukemia) : The cytotoxic effect and the increase in Fas and Fas L were dependent on Akt activation
Wang et al., J Biol Chem 1998 : Furthermore, cotransfected wild-type PKB/Akt increased FAS promoter activity in the absence of insulin and a loss of insulin responsiveness of the FAS promoter