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AKT2 — TMED7

Text-mined interactions from Literome

Graff et al., J Biol Chem 2000 (Disease Progression...) : Furthermore, expression of the p27 ( Kip1 ) cell cycle regulator was diminished in LNAI cells, consistent with the notion that AKT directly inhibits AFX/Forkhead mediated transcription of p27 ( Kip1 ) ... Together, these data implicate increased AKT activity in prostate tumor progression and androgen independence and suggest that diminished p27 ( Kip1 ) expression, which has been repeatedly associated with prostate cancer progression, may be a consequence of increased AKT activity
Yakes et al., Cancer Res 2002 (Breast Neoplasms) : Herceptin induced inhibition of phosphatidylinositol-3 kinase and Akt Is required for antibody mediated effects on p27 , cyclin D1, and antitumor action
Carloni et al., Clin Cancer Res 2005 (Carcinoma, Hepatocellular...) : Furthermore, ABT-100 inhibited Akt dependent p27 ( Kip1 ) phosphorylation and this event was associated with increased levels of p27 ( Kip1 ) in the nucleus and reduced activity of the cyclin dependent kinase 2
Rattan et al., J Biol Chem 2005 (Neoplasms, Experimental) : Moreover, constitutive active AMPK arrested the cells in S-phase by inducing the expression of p21, p27 , and p53 proteins and inhibiting Akt phosphorylation, suggesting the involvement of AMPK
van Duijn et al., Prostate 2006 (Prostatic Neoplasms) : We compared the involvement of PI3K/PTEN/Akt signaling in the regulation of the cell-cycle regulator p27 ( kip1 ) and investigated the mechanism of PI3K/PTEN/Akt modulation of p27 ( kip1 ) in the prostate cancer cell lines LNCaP, PC346, PC3, and DU145 ... Downregulation of PTEN in DU145 cells also showed PTEN/Akt dependent regulation of Skp2 and p27 ( kip1 )
Rosner et al., Hum Mol Genet 2007 : Akt mediated phosphorylation of p27 , but not of tuberin, negatively regulates tuberin 's potential to trigger p27 nuclear localization
Bagui et al., Cell cycle (Georgetown, Tex.) 2009 : Inhibition of p27 ( Kip1 ) gene expression by PDGF required protein synthesis and histone deacetylase activity but not Akt or ERK activity
Lee et al., Clin Cancer Res 2009 (Mammary Neoplasms, Experimental) : Mixed tocopherols increased the expression of p21, p27 , caspase-3, and peroxisome proliferator activated receptor-gamma, and inhibited AKT and estrogen signaling in mammary tumors
Kim et al., J Toxicol Environ Health 2010 (Prostatic Neoplasms) : Knockdown of PP2A-Ca with siRNA reduced p27 ( kip1 ) levels in the presence of Akt inhibitor
Gopinath et al., Mol Oncol 2011 (Glioma) : In the present study, shRNA against cathepsin B and uPAR as well as specific inhibitors, Wortmannin ( 10 µM ) and U0126 ( 10 µM ), were used to determine the roles of AKT and ERK signaling on p27 expression
Wen et al., Oncogene 2012 (Helicobacter Infections...) : These results show that H. pylori infection induces AKT/PI3K mediated phosphorylation of p27 at T157 and T198 to cause cytoplasmic p27 mislocalization in gastric cancer, and that p27 mislocalization is an adverse prognostic feature in gastric cancer
Fang et al., J Biol Chem 2012 (Prostatic Neoplasms) : This rapid androgen stimulated p27 degradation was mediated by AKT through the phosphorylation of p27 T157