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AKT2 — TP53

Text-mined interactions from Literome

Fang et al., EMBO J 2001 (MAP Kinase Signaling System) : Additionally, the PI3K/Akt pathway was activated in response to p53 signaling through HB-EGF induction, and inhibition of MAPK and Akt activation after DNA damage decreased cell survival in wild-type p53 containing cells
Mayo et al., Proc Natl Acad Sci U S A 2001 (Translocation, Genetic) : Expression of constitutively active Akt promotes nuclear entry of Mdm2, diminishes cellular levels of p53 , and decreases p53 transcriptional activity
Lin et al., Cancer Res 2002 (Breast Neoplasms) : Expression of wt p53 did not cause a reduction in the phosphorylation of three unrelated protein kinases in other signal transduction pathways, AKT , extracellular signal regulated kinase ( ERK ) 1, and ERK2 or a reduction of phosphorylation of epidermal growth factor receptor
Gottlieb et al., Oncogene 2002 : Taken together, our findings suggest that depending on the balance of signals, p53 dependent downregulation of Akt may promote an irreversible commitment to apoptotic cell death, whereas effective recruitment of Akt by appropriate survival signals may lead to activation of Mdm2, inactivation of p53, and eventually inhibition of p53 dependent apoptosis
Ogawara et al., J Biol Chem 2002 : In this study, we find that expression of Akt reduces the protein levels of p53 , at least in part by enhancing the degradation of p53
Oren et al., Biochem Pharmacol 2002 (Neoplasms) : Similarly, Akt can block p53 activation by potentiating Mdm2, whereas activated p53 can tune down Akt in several different ways
Oren et al., Ann N Y Acad Sci 2002 (Neoplasms) : Similarly, Akt can block p53 activation by potentiating Mdm2, whereas activated p53 can tune down Akt in several different ways
Nesslinger et al., Cancer Res 2003 (Neoplasms, Hormone-Dependent...) : These observations suggest that GOF p53 mutants mediate the AI growth of LNCaP cells in an AR-independent fashion, and that both Akt and Bcl-2 are not involved in this process
Ostrakhovitch et al., Arch Biochem Biophys 2004 (Breast Neoplasms) : In contrast, in MCF-7 cells with wild type p53 and estrogen receptor, there was no change in Akt activation, while suppression of p53 activity by pifithrin-alpha increased phosphorylation of Akt after the treatment with copper
Carlson et al., J Surg Res 2004 : FAK and Akt are activated in the attached fibroblast populated collagen matrix whereas the p53 level is relatively low ; matrix detachment downregulates FAK and Akt activity and induces p53
Jeong et al., Oncogene 2005 (Cell Transformation, Viral) : Activated AKT regulates NF-kappaB activation, p53 inhibition and cell survival in HTLV-1 transformed cells ... Treatment of C81 cells with LY294002 resulted in an increase in the p53-responsive gene MDM2, suggesting a role for AKT in the Tax mediated regulation of p53 transcriptional activity
Rattan et al., J Biol Chem 2005 (Neoplasms, Experimental) : Moreover, constitutive active AMPK arrested the cells in S-phase by inducing the expression of p21, p27, and p53 proteins and inhibiting Akt phosphorylation, suggesting the involvement of AMPK
Schmitz et al., Virchows Arch 2006 (Breast Neoplasms...) : Besides the prognostic impact of pMDM2, our findings suggest that Akt mediated modulation of the MDM2/p53 complex contributes to increased tumour aggressiveness especially in p53 negative breast cancers
Yang et al., Cancer Res 2006 (Breast Neoplasms...) : Akt activation can enhance p53 degradation, but its role in DNA damage response is not clear
Yang et al., Cancer Res 2006 (Ovarian Neoplasms) : Akt attenuated mitochondrial p53 accumulation and Smac/cytochrome c/Omi release and conferred resistance
Lei et al., Cancer Cell 2006 (Prostatic Neoplasms) : NKX3.1 stabilizes p53 , inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss
Burdick et al., Carcinogenesis 2006 (Breast Neoplasms) : In addition, we found that BPDE increased p53 activity and apoptosis in MCF-10A ; however, transient transfection of constitutively active Akt attenuated both BPDE dependent apoptosis and p53 activity
Shankar et al., Int J Oncol 2007 (Prostatic Neoplasms) : Overexpression of constitutively active AKT inhibited curcumin induced p53 translocation to mitochondria, and Smac release to cytoplasm, whereas inhibition of AKT by dominant negative AKT enhanced curcumin induced p53 translocation to mitochondria and Smac release
Kim et al., Mol Cancer Res 2007 : ERK1/2 or Akt was not responsible for p53 repression due to G alpha(12) deficiency
Groskreutz et al., J Immunol 2007 : These findings reveal that RSV decreases p53 by enhancing Akt/Mdm2 mediated p53 degradation, thereby delaying apoptosis and prolonging survival of airway epithelial cells
Facchin et al., Cell Mol Life Sci 2007 : We show that recombinant PRPK is phosphorylated in vitro by Akt and its phospho-form is recognized by a Ser250-phospho-specific antibody ; that cell co-transfection with Akt along with wild-type PRPK, but not with its Ser250Ala mutant, results in increased PRPK phosphorylation ; and that the phosphorylation of p53 at Ser15, the only known substrate of PRPK, is markedly increased by co-transfection of Akt with wild-type PRPK, but not PRPK dead mutant, and is abrogated by cell treatment with the Akt pathway inhibitor LY294002
Hlobilkova et al., Neoplasma 2007 (Astrocytoma...) : The changes in PTEN and p53 expression, and activation of PKB/Akt are events in the early stages of astrocytomagenesis
Fraser et al., Int J Cancer 2008 (Ovarian Neoplasms) : Furthermore, activation of Akt inhibited the cisplatin induced upregulation of PUMA, and suppressed cisplatin induced p53 phosphorylation, while inhibition of Akt increased total and phospho-p53 contents and sensitized p53 wild-type, chemoresistant cells to cisplatin induced apoptosis
Jeong et al., Virology 2008 : Since AKT inhibitors simultaneously inhibit NF-kappaB and activate p53 , these drugs should be promising candidates for HTLV-1 associated cancer therapy
Kimura et al., Development 2008 : In the transgenic PGCs, AKT activation induced phosphorylation of GSK3, which inhibits its kinase activity ; enhanced the stability and nuclear localization of MDM2 ; and suppressed p53 phosphorylation, which is required for its activation
Shankar et al., Oncogene 2008 : Protein kinase C epsilon confers resistance of MCF-7 cells to TRAIL by Akt dependent activation of Hdm2 and downregulation of p53 ... Since Akt can regulate p53 , we have examined the involvement of p53 in PKC epsilon mediated TRAIL resistance ... Depletion of Akt from MCF-7/PKC epsilon cells resulted in an increase in p53 and Bid
Vaillancourt et al., Arthritis Res Ther 2008 (Osteoarthritis) : Our study of signalling pathways revealed that HNE suppressed pro-survival Akt kinase activity but, in contrast, induced Fas/CD95 and p53 expression in chondrocytes
Wang et al., J Biol Chem 2009 (Carcinoma, Hepatocellular...) : Notch1 signaling sensitizes tumor necrosis factor related apoptosis inducing ligand induced apoptosis in human hepatocellular carcinoma cells by inhibiting Akt/Hdm2 mediated p53 degradation and up-regulating p53 dependent DR5 expression ... Taken together, Notch1 signaling sensitizes TRAIL induced apoptosis in HCC cells by inhibiting Akt/Hdm2 mediated p53 degradation and up-regulating p53 dependent DR5 expression
Li et al., Cancer Lett 2009 (Adenocarcinoma...) : Arsenic trioxide induces apoptosis and G2/M phase arrest by inducing Cbl to inhibit PI3K/Akt signaling and thereby regulate p53 activation
Zhou et al., Cell Mol Immunol 2009 : PI3K/AKT mediated p53 down-regulation participates in CpG DNA inhibition of spontaneous B cell apoptosis
Ouyang et al., Cell Biol Int 2009 (Ovarian Neoplasms) : Moreover, genistein enhances the phosphorylation and activation of p53 , while decreases the ratio of Bcl-2/Bax and Bcl-xL/Bax and the level of phosphorylated Akt , which result in cells undergoing apoptosis
Fenouille et al., Oncogene 2011 (Melanoma) : Here, we show that SPARC has a cell-autonomous survival activity, which requires Akt dependent regulation of p53
Park et al., Mol Carcinog 2012 (Colonic Neoplasms...) : HFD feeding increased tumor tissue levels of Ki67, cyclin A, cyclin D1, CDK2, Bcl-xL, and Bcl-2 ; reduced p53 levels and TUNEL positive apoptotic cells ; increased the levels of CD45, CD68, CD31, VEGF, P-VEGF receptor-2, iNOS, and COX-2 as well as hemoglobin content ; and increased the levels of HIF-1a, P-STAT3-Y705, P-STAT3-S727, P-I?B-a, P-p65, p65, P-c-Jun, P-Akt , P-ERK1/2, P-p38, and P-SAPK/JNK
Krishnan et al., Dig Dis Sci 2012 (Barrett Esophagus) : Immunohistochemistry and Western blot analysis was performed for Pß-Catenin ( 552 ) ( Akt mediated phosphorylation of ß-Catenin ), Ki-67 and p53
Ummanni et al., Molecular cancer 2011 (Prostatic Neoplasms) : In further analysis, we found evidence that exogenous expression of UCHL1 suppress LNCaP cells growth probably via p53 mediated inhibition of Akt/PKB phosphorylation and also via accumulation of p27kip1 a cyclin dependant kinase inhibitor of cell cycle regulating proteins
Zhang et al., Int J Radiat Oncol Biol Phys 2012 (Lung Injury...) : Apoptosis correlated with increased PTEN expression, inhibition of downstream PI3K/AKT signaling, and increased p53 and Bax protein levels
Zhou et al., Kidney Int 2012 (Acute Kidney Injury...) : In vitro activation of ß-catenin by Wnt1 or stabilization of ß-catenin protected tubular epithelial cells from apoptosis, activated Akt , induced survivin, and repressed p53 and Bax expression
Xue et al., Cell cycle (Georgetown, Tex.) 2012 : These data suggest that Akt is an important positive regulator of CSN6, and that activation of Akt in many types of cancer could lead to abnormal elevation of CSN6 and result in downregulated p53 and increased DNA damage, which promotes cancer cell growth
Tang et al., Curr Cancer Drug Targets 2013 (Brain Neoplasms...) : Furthermore, inhibition of the miR-183/96/182 cluster induced ROS mediated AKT/survival independent of three target genes FGF9, CPEB1, and FOXO1, and inhibition of the miRNA cluster induced p53/apoptosis signaling, which was dependent on these same genes
Sinha et al., Cell death & disease 2013 (Brain Neoplasms...) : Transfection with TIGAR mutant ( i ) decreased apoptosis and ?H2AX foci formation ( ii ) decreased p53 ( iii ) elevated ROS and ( iv ) increased Akt/Erk activation in cells cotreated with NCS and TNFa
Dai et al., J Biol Chem 2013 : The activated AKT phosphorylated MDM2 at Ser ( 166 ) and promoted degradation of the tumor suppressor p53
Cordero-Herrera et al., Nutr Cancer 2013 : In this study, the in vitro anticancer effects of ECG on SW480 colon cancer cell line was investigated by analyzing the cell cycle, apoptosis, key proteins involved in cellular survival/proliferation, namely AKT/phosphatidylinositol-3-kinase (PI3K) and mitogen activated protein kinases ( MAPKs ), and the role of p53 in these processes ... Exposure of SW480 cells to ECG also led to apoptosis as determined by time dependent changes in caspase-3 activity, MAPKs [ extracellular regulated kinase (ERK), p38, and c-jun amino-terminal kinase ( JNK ) ], p21 and p53 activation, and AKT inhibition