Gene interactions and pathways from curated databases and text-mining

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AKT3 — AKT3

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: AKT3 → AKT3 (hasVariant)
  • OpenBEL Selventa BEL large corpus: AKT3 → AKT3 (directlyIncreases, AKT3 Activity)
    Evidence: Relative kinase activities of both splice variants were reflected in the phosphorylation status of Thr-305, the lower level of phosphorylation of HA-PKB?1 correlating with lesser activation (Fig.5 C). Finally, by monitoring the phosphorylation status of Ser-472 of HA-PKB? under the different conditions we found that okadaic acid treatment led to phosphorylation at Ser-472 but not Thr-305 and to low levels of kinase activation (Fig.5 D).
  • OpenBEL Selventa BEL large corpus: AKT3 → AKT3 (directlyIncreases, AKT3 Activity)
    Evidence: When Thr-305 of HA-PKB?1 was mutated to an alanine that cannot be phosphorylated (HA-PKB?1T305A), the activation was abolished (Fig. 4 A).
  • OpenBEL Selventa BEL large corpus: AKT3 → AKT3 (directlyIncreases, AKT3 Activity)
    Evidence: three isoforms, AKT1 (PKBalpha), AKT2 (PKBbeta) and AKT3 (PKBgamma) they all contain a central kinase domain with an activation-loop phosphorylation site, Thr308, and a conserved, regulatory C-terminal phosphorylation site, Ser473

Text-mined interactions from Literome

Hanrahan et al., Cancer Discov 2012 (Cystadenocarcinoma, Serous...) : Inhibition of AKT1 caused growth arrest in a subset of ovarian cell lines, but not in those with AKT3 expression, which required pan-AKT inhibition
Tokuda et al., Hum Mol Genet 2011 (Disease Susceptibility...) : An in vitro kinase assay revealed that Akt3 ( Nmf350 ) confers higher enzymatic activity, suggesting that Akt3 ( Nmf350 ) might enhance AKT signaling in the brain
Peng et al., Genes Dev 2003 (Abnormalities, Multiple...) : These functions of Akt were uncovered despite the observed lower level of Akt activity mediated by Akt3 in Akt1/Akt2 DKO cells, suggesting that a critical threshold level of Akt activity is required to maintain normal cell proliferation, growth, and differentiation