Gene interactions and pathways from curated databases and text-mining

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AKT3 — PLD3

Text-mined interactions from Literome

Wang et al., Biochem Pharmacol 2003 : Collectively, these results indicate that the inhibition by CCY1a of fMLP induced O2 ( .- ) generation in rat neutrophils can probably be attributed to the increase in cAMP levels, and to the blockade of Ca2+ entry, suppression of Akt , and PLD activation via cAMP independent mechanisms
Kam et al., FASEB J 2004 : PDGF induced marked phosphorylation of Akt ( a PI3K target ) but this was not affected by PLD deficiency ... LPA caused much less phosphorylation of Akt and this was dependent on PLD activity
Li et al., J Pharmacol Exp Ther 2005 : Diacylglycerol kinase inhibitor II diminished Ang II-induced and diC8-phosphatidic acid ( PA ) -increased Akt phosphorylation, suggesting that PLD dependent Akt activation is mediated by PA
Kim et al., Cancer Res 2006 : Etoposide induced activation of Akt was potentiated by overexpression of PLD and PLD stimulated suppression of Egr-1 was blocked by inhibition of phosphatidylinositol 3-kinase/Akt survival pathway at the both transcriptional and posttranscriptional levels
Toschi et al., Mol Cell Biol 2009 : Suppression of PLD also blocked insulin stimulated Akt phosphorylation at Ser473 and the mTORC2 dependent phosphorylation of PRAS40
Zhang et al., Sheng Wu Gong Cheng Xue Bao 2009 : [ Over-expression of phospholipase D3 inhibits Akt phosphorylation in C2C12 myoblasts ] ... Our observations indicated that PLD3 over expression may inhibit Akt phosphorylation and further block the transduction of insulin signaling in C2C12 cells