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ANAPC5 — CDK1
Pathways - manually collected, often from reviews:
-
KEGG Cell cycle:
Complex of 14 proteins
→
Complex of CCNB1-CCNB2-CCNB3-CDK1
(protein-protein, inhibition)
-
Reactome Reaction:
ANAPC5
→
CDK1
(reaction)
Ohtoshi et al., Biochem Biophys Res Commun 2000, Geley et al., J Cell Biol 2001, Golan et al., J Biol Chem 2002, Kraft et al., EMBO J 2003
-
Reactome Reaction:
ANAPC5
→
CDK1
(indirect_complex)
Ohtoshi et al., Biochem Biophys Res Commun 2000, Geley et al., J Cell Biol 2001
Text-mined interactions from Literome
Liu et al., Proc Natl Acad Sci U S A 2002
:
Plks have been reported to mediate multiple mitotic processes, including bipolar spindle formation, activation of Cdc25C, actin ring formation,
centrosome maturation, and
activation of the
anaphase promoting complex
Pomerening et al., Nat Cell Biol 2003
:
At the core of the oscillator is a negative feedback loop ; cyclins accumulate and produce active mitotic Cdc2-cyclin B ;
Cdc2 activates the
anaphase promoting complex (APC) ; the APC then promotes cyclin degradation and resets Cdc2 to its inactive, interphase state
Margottin-Goguet et al., Dev Cell 2003
:
Progression through mitosis occurs because cyclin
B/Cdc2 activation
induces the
anaphase promoting complex (APC) to cause cyclin B destruction and mitotic exit
Liu et al., Cell cycle (Georgetown, Tex.) 2003
(Neoplasms) :
Genetic and biochemical experiments with several different organisms have documented that polo-like kinases are involved in many aspects of the cell cycle, such as activation of
Cdc2 , centrosome assembly and maturation,
activation of the
anaphase promoting complex (APC) during the metaphase-anaphase transition, and cytokinesis
Pomerening et al., Cell 2005
:
The cell-cycle oscillator includes an essential negative-feedback loop :
Cdc2 activates the
anaphase promoting complex (APC) , which leads to cyclin destruction and Cdc2 inactivation
Mitra et al., Cell cycle (Georgetown, Tex.) 2006
:
Dual
regulation of the
anaphase promoting complex in human cells by cyclin A-Cdk2 and cyclin
A-Cdk1 complexes
Man et al., Protein Cell 2011
(Breast Neoplasms...) :
CUEDC2 is phosphorylated by
Cdk1 during mitosis and
promotes the release of
anaphase promoting complex or cyclosome ( APC/C ) from checkpoint inhibition
Lianga et al., J Cell Biol 2013
:
Here we show that the budding yeast Wee1 kinase, Swe1, also restrains the metaphase-to-anaphase transition by preventing
Cdk1 phosphorylation and
activation of the mitotic form of the
anaphase promoting complex/cyclosome ( APC ( Cdc20 ) )
Patra et al., Genes Dev 1998
:
Xe-p9, a Xenopus Suc1/Cks protein, is essential for the
Cdc2 dependent phosphorylation of the
anaphase- promoting complex at mitosis