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ANXA1 — EGFR

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: ANXA1 → EGFR (increases, ANXA1 Activity)
  Evidence: that lipocortin I and the 35 kd substrate for the EGF-receptor/kinase from A431 cells are the same protein.

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: ANXA1 — EGFR (in vivo) Radke et al., FEBS Lett 2004*
• IRef Intact Interaction: Complex of 59 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
• IRef Intact Interaction: ANXA1 — EGFR (physical association, anti tag coimmunoprecipitation) Radke et al., FEBS Lett 2004*
• IRef Intact Interaction: ANXA1 — EGFR (colocalization, imaging technique) Radke et al., FEBS Lett 2004*
• IRef Intact Interaction: ANXA1 — EGFR (physical association, ubiquitin reconstruction) Deribe et al., Science signaling 2009

Text-mined interactions from Literome

Koese et al., Oncogene 2013 : Stable expression of the cytosolic N-terminal mutant AnxA61-175 , which can not promote PKCa membrane recruitment, does not increase T654-EGFR phosphorylation or the association of PKCa with EGFR
Futter et al., J Cell Biol 1993 : Our observations, together with the known properties of annexin I in mediating membrane fusion, suggest that inward vesiculation in MVBs is induced by the EGF-R and is mediated by phosphorylated annexin I