Gene interactions and pathways from curated databases and text-mining

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ARF3 — MYC

Text-mined interactions from Literome

Qi et al., Nature 2004 (Cell Transformation, Neoplastic) : Here we show that ARF can inhibit c-Myc by a unique and direct mechanism that is independent of p53
Dang et al., Cancer Cell 2005 (Burkitt Lymphoma...) : Acute MYC expression increases p53 or ARF levels and induces apoptosis, and previous transgenic animal studies revealed frequent inactivating mutations of p53 or p19ARF in transgenic Myc induced lymphomas
Li et al., Cell cycle (Georgetown, Tex.) 2009 : Whereas loss of ARF accelerates c-Myc induced tumorigenesis, NPM overexpression enhances c-Myc transformation
Li et al., Oncogene 2013 : Here, we show that NPM is necessary for the localization of c-Myc protein to nucleoli, whereas c-Myc nucleolar localization is independent of p53, Mdm2 and ARF
Zhang et al., Proc Natl Acad Sci U S A 2013 (Cell Transformation, Neoplastic) : ARF inhibits the interaction of c-Myc with the E3 ubiquitin ligase Skp2
Chen et al., Mol Cell 2013 : Although the mRNA levels of ARF are induced in both scenarios, the accumulation of ARF protein occurs only when ULF mediated degradation of ARF is inhibited by c-Myc overexpression