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ABL1 — ARG2
Text-mined interactions from Literome
Hawk et al., Cancer Res 2002
:
We showed that the
Arg to Leu mutation in the Phe-Leu-Val-Arg-Glu-Ser ( FLVRES ) sequence of the SH2 domain, known to interfere with phosphotyrosine sequence binding, did not
block the binding of Bcr first exon sequences to the
Abl SH2 domain
Cao et al., J Biol Chem 2003
(Breast Neoplasms) :
The results further demonstrate that the interaction between c-Abl and Arg involves
c-Abl mediated phosphorylation of
Arg
Cao et al., Oncogene 2005
(Breast Neoplasms) :
The results further demonstrate that
c-Abl mediated phosphorylation of
Arg on Y-261 similarly confers Arg stabilization
Ganguly et al., Genes & cancer 2012
:
Accumulating evidence now indicates that c-Abl and/or
Arg are activated in some solid tumor cell lines via unique mechanisms that do not involve gene mutation/translocation, and
c-Abl/Arg activation
promotes matrix degradation, invasion, proliferation, tumorigenesis, and/or metastasis, depending on the tumor type