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ARSK — BAX
Text-mined interactions from Literome
Hou et al., Cancer Lett 2008
(Osteosarcoma) :
In addition,
ASK1 , p38 and JNK siRNA
reduced HBI induced p53 phosphorylation and
Bax expression
Shi et al., FEBS Lett 2011
:
HG induced activation of apoptosis signal regulating kinase-1 ( ASK1 ) in a time dependent manner in MMCs. Treatment with antioxidant, tempol, or knockdown of TXNIP in MMCs reduced HG-mediated apoptosis, expression of cleaved caspase-3,
Bax/Bcl-2 ratio and
activation of
ASK1