Gene interactions and pathways from curated databases and text-mining

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ARSK — BAX

Text-mined interactions from Literome

Hou et al., Cancer Lett 2008 (Osteosarcoma) : In addition, ASK1 , p38 and JNK siRNA reduced HBI induced p53 phosphorylation and Bax expression
Shi et al., FEBS Lett 2011 : HG induced activation of apoptosis signal regulating kinase-1 ( ASK1 ) in a time dependent manner in MMCs. Treatment with antioxidant, tempol, or knockdown of TXNIP in MMCs reduced HG-mediated apoptosis, expression of cleaved caspase-3, Bax/Bcl-2 ratio and activation of ASK1