Gene interactions and pathways from curated databases and text-mining

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ATF2 — IL1B

Text-mined interactions from Literome

Clerk et al., J Mol Cell Cardiol 1999 (MAP Kinase Signaling System) : IL-1 beta and TNF alpha stimulated the phosphorylation of c-Jun and ATF2
Robbins et al., Arthritis Rheum 2000 : IL-1beta also stimulated phosphorylation of p38 MAPK, SAPK/JNK, and ATF-2
Sooranna et al., J Cell Physiol 2007 (MAP Kinase Signaling System) : All three stimuli increased PGHS-2 and IL-8 mRNA expression in a MAPK dependent manner, but while the MAPK inhibitors reduced the IL-1beta induced activation of activating transcription factor (ATF)-2 , liver activating protein (LAP) and c-jun, the stretch induced increase in LAP was unaffected by MAPK-inhibition and only JNK inhibition appeared to reduce c-jun activation
Tseng et al., Biochem Pharmacol 2008 : HE-145 specifically suppressed IL-1beta induced c-jun mRNA and protein expression and prevented c-jun mediated AP-1 DNA binding activity, whereas it had no effect on IL-1beta induced activation of JNK, p38 and ATF2