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ATXN3 — CASP1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: ATXN3 — CASP1 Wellington et al., J Biol Chem 1998
• IRef Bind_translation Interaction: ATXN3 — CASP1 (experimental interaction detection) Wellington et al., J Biol Chem 1998
• IRef Hprd Interaction: ATXN3 — CASP1 (in vitro) Wellington et al., J Biol Chem 1998
• IRef Ophid Interaction: CASP1 — ATXN3 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Berke et al., J Neurochem 2004 (Machado-Joseph Disease) : Broad-spectrum caspase inhibitors block ataxin-3 proteolysis and studies suggest that caspase-1 is a primary mediator of cleavage ... Finally, caspase mediated cleavage of expanded ataxin-3 resulted in increased ataxin-3 aggregation, suggesting a potential role for caspase mediated proteolysis in spinocerebellar ataxia type-3 pathogenesis
Wang et al., J Neurochem 2007 (Machado-Joseph Disease) : p45 , an ATPase subunit of the 19S proteasome, interacts with ataxin-3 in vitro and stimulates the degradation of ataxin-3 in an in vitro reconstituted degradation assay system ... The effect of p45 on ataxin-3 degradation is blocked by MG132, a proteasome inhibitor