Griffin et al., Crit Care Med 2004
(Brain Ischemia...) :
In these cells, APC blunts hypoxia induced increases in p53 messenger RNA and protein, reduces pro-apoptotic Bax , and increases anti-apoptotic Bcl-2, thereby inhibiting mitochondrial dependent apoptosis
Ding et al., J Korean Med Sci 2010
(Myocardial Reperfusion Injury) :
APC reduced the expression of pro-apoptotic genes, Bax and cytochrome c