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BCL2 — BDNF
Text-mined interactions from Literome
Schäbitz et al., Stroke 2000
(Brain Ischemia) :
In this experiment we studied the
effect of intravenous
BDNF delivered after focal cerebral ischemia on neurological outcome, infarct size, and expression of proapoptotic and antiapoptotic proteins Bax and
Bcl-2 , respectively
Lim et al., J Neurosci Res 2008
:
Inhibition of ERKs inhibited the
BDNF stimulated up-regulation of p35 and
Bcl2
Kajiya et al., J Cell Physiol 2009
(Necrosis) :
BDNF enhanced phosphorylated Akt levels, NF-kappaB activity in the nucleus,
Bcl-2 mRNA levels, and mitochondrial membrane potential
Chao et al., Brain Pathol 2011
:
Brain derived neurotrophic factor enhances
Bcl-xL expression through protein kinase casein kinase 2-activated and nuclear factor kappa B-mediated pathway in rat hippocampus ... Moreover, transfection of CK2a small interfering RNA ( siRNA ) blocked the enhancing
effect of
BDNF on NF-?B phosphorylation and
Bcl-xL expression ... Transfection of NF-?BS529A, the dominant negative mutant of NF-?B, prevented the enhancing
effect of
BDNF on
Bcl-xL expression
Allsopp et al., Eur J Neurosci 1995
:
Role of
Bcl-2 in the
brain derived neurotrophic factor survival response ... Our findings suggest that
Bcl-2 is
required for the
BDNF survival response and that alternative, Bcl-2 independent survival mechanisms operate in sensory and parasympathetic neurons exposed to CNTF