◀ Back to MYC

BCR — MYC

Pathways - manually collected, often from reviews:

• KEGG Chronic myeloid leukemia: ABL1/BCR → MYC (protein-protein, indirect effect)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: BCR — MYC (physical association, affinity chromatography technology) Koch et al., Cell cycle (Georgetown, Tex.) 2007
• IRef Intact Interaction: Complex of 222 proteins (association, tandem affinity purification) Koch et al., Cell cycle (Georgetown, Tex.) 2007

Text-mined interactions from Literome

Xie et al., Oncogene 2002 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Jak2 is involved in c-Myc induction by Bcr-Abl ... In summary, our findings indicate that Jak2 mediates the increase in c-Myc expression that is induced by Bcr-Abl
Ress et al., EMBO Rep 2005 : Bcr can form a complex with beta-catenin and negatively regulate expression of c-Myc ... Expression of Bcr in the human colon carcinoma cell line HCT116, which has a high level of endogenous beta-catenin, leads to reduced c-Myc expression
Clark et al., Oncology 2006 (Leukemia) : Since Bcr/Abl induces constitutive expression of c-Myc , which is necessary for cell cycle transit from G1 into the S phase, we tested whether POH causes growth arrest by inhibiting expression of c-Myc
Andrews et al., J Immunol 2009 : T1, in contrast to follicular mature B cells, failed to express key NF-kappaB target genes in response to BCR engagement and exhibited a striking defect in assembly of an active transcriptional complex at the promoter of the survival and proliferative genes A1 and c-Myc