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BCR — TP53

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: BCR — TP53 (direct interaction, two hybrid) Stelzl et al., Cell 2005
• IRef Hprd Interaction: TP53 — BCR (two hybrid) Stelzl et al., Cell 2005
• IRef Intact Interaction: Complex of 58 proteins (physical association, anti tag coimmunoprecipitation) Sowa et al., Cell 2009
• IRef Intact Interaction: BCR — TP53 (physical association, two hybrid pooling approach) Stelzl et al., Cell 2005
• IRef Ophid Interaction: BCR — TP53 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Keeshan et al., Leukemia 2001 : Despite the drug-resistant phenotype, high Bcr-Abl levels concomitantly increased the expression of p53 , p21, Bax and down-regulated Bcl-2
Hase et al., J Biol Chem 2002 : BCR ligation resulted in p53 activation including its phosphorylation at Ser ( 15 ), nuclear translocation, and target gene p53AIP1 induction
Wendel et al., Proc Natl Acad Sci U S A 2006 (Disease Progression...) : We show that the tumor suppressor p53 is selectively activated by imatinib in BCR-ABL expressing cells as a result of BCR-ABL kinase inhibition