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BGLAP — TNF

Text-mined interactions from Literome

Ou et al., Clin Rheumatol 2002 : Osteocalcin levels were decreased and TNF-alpha increased in active JIA status, but these differences showed no statistical significance
Dobreva et al., Immunopharmacol Immunotoxicol 2007 : C3bgp induced moderate TNF-alpha production in human PBMC and primary monocytes
Nanes et al., Endocrinology 1991 (Osteosarcoma) : Tumor necrosis factor-alpha inhibits 1,25-dihydroxyvitamin D3-stimulated bone Gla protein synthesis in rat osteosarcoma cells ( ROS 17/2.8 ) by a pretranslational mechanism ... To further test this hypothesis and to evaluate the mechanism of TNF alpha action, we studied the effect of TNF alpha on synthesis of the osteoblast-specific bone Gla protein (BGP) by ROS 17/2.8 cells, which have the osteoblast phenotype ... The TNF alpha inhibition of BGP secretion was independent of changes in [ 14C ] leucine incorporation, suggesting that TNF alpha did not have a general inhibitory effect on total protein synthesis ... The effect of TNF alpha on steady state BGP mRNA levels was not prevented by treatment of cells with cycloheximide, suggesting that TNF induced new protein synthesis was not required for TNF alpha action ... These results suggest that the mechanism of TNF alpha inhibition of BGP synthesis includes a pretranslational site and support the hypothesis that TNF alpha inhibits bone formation by a selective inhibition of matrix protein production
Mayur et al., J Bone Miner Res 1993 : We have previously shown that TNF-alpha inhibits 1,25- ( OH ) 2D3 stimulated synthesis of bone gla protein (BGP) , an abundant and osteoblast-specific matrix constituent
Li et al., Mol Cell Biol 1993 (Osteosarcoma) : Osteocalcin , the major noncollagenous protein in bone, is inhibited by TNF at the transcriptional level