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BMP10 — PTH
Text-mined interactions from Literome
Nakao et al., Bone 2009
:
Parathyroid hormone enhances
bone morphogenetic protein activity by increasing intracellular 3 ', 5'-cyclic adenosine monophosphate accumulation in osteoblastic MC3T3-E1 cells ... H89 ( PKA inhibitor ) almost completely abolished
PTH actions on
BMP signaling ... These results suggest that
PTH enhances
BMP signaling when PTH induced intracellular cAMP level is maintained for a few hours, accelerating BMP actions to promote osteoblastic function and anabolic actions of new bone formation
Yang et al., Ann N Y Acad Sci 2010
(Bone Diseases, Developmental) :
This study provides an in vivo tool to study the role of BMPRII in
BMP/Smad signaling and the
regulation of this pathway by
PTH and Wnts