Imai et al., J Bone Miner Res 2005
(Fractures, Bone) :
Hepatocyte growth factor (HGF) is activated and the expression of BMP receptors ( BMPRs ) is induced around the fracture site during the early phase of fracture repair
Standal et al., Blood 2007
(Bone Resorption...) :
Here we show that HGF inhibited bone morphogenetic protein ( BMP ) -induced in vitro osteoblastogenesis ... BMP induced nuclear translocation of receptor activated Smads was inhibited by HGF, providing a possible explanation of how HGF inhibits BMP signaling
Ye et al., Int J Oncol 2007
(Bone Neoplasms...) :
The effect of HGF on BMP receptor expression was further investigated in a nude mouse PC-3 xenograft model
Dankbar et al., J Orthop Res 2007
(Osteoarthritis) :
Effects of HGF on the secretion of TGF-beta1 and BMP-2 by chondrocytes, fibroblast-like synovial cells ( FLS ), and macrophages as well as HGF induced secretion of MCP-1 by FLS and chondrocytes were determined by ELISA