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BCL2 — CAPN3
Text-mined interactions from Literome
Gao et al., J Cell Biochem 2000
:
Finally,
Bcl-2 overexpression
inhibited etoposide induced
calpain activation, Bax cleavage, cytochrome c release, and apoptosis
Choi et al., J Neurochem 2001
(Necrosis) :
Cleavage of Bax is mediated by caspase dependent or -independent
calpain activation in dopaminergic neuronal cells : protective role of
Bcl-2
Das et al., J Neurooncol 2008
(Brain Neoplasms...) :
The events of apoptosis included increase in expression of Bax, down regulation of
Bcl-2 and baculoviral inhibitor-of-apoptosis protein (IAP) repeat containing ( BIRC ) proteins, mitochondrial release of cytochrome c and Smac into the cytosol, increase in intracellular free [ Ca ( 2+ ) ], and
activation of
calpain , caspase-9, and caspase-3
Das et al., Brain Res 2008
(Brain Neoplasms...) :
Besides, apoptosis was associated with alterations in expression of pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins resulting in an increase in Bax :
Bcl-2 ratio, mitochondrial release of cytochrome c and Smac, downregulation of selective baculoviral inhibitor-of-apoptosis repeat containing ( BIRC ) molecules, an increase in intracellular free [Ca2+ ], and
activation of
calpain and caspase-3
Leon et al., J Neurosci Res 2009
:
Here we propose the mechanisms underlying glutamate induced apoptosis and taurine 's inhibition of glutamate induced apoptosis to be as follows : glutamate stimulation induces [Ca2+ ] ( i ) elevation, which in turn activates calpain ; activation of
calpain leads to a reduction of
Bcl-2 : Bax ratios ; with decreased Bcl-2 : Bax ratios Bax homodimers form, Bax homodimerization, and translocation to the mitochondria result in the release of cytochrome c ; released cytochrome c in turn activates a downstream caspase cascade leading to apoptosis
Liu et al., J Gastroenterol Hepatol 2009
:
Na+/H+ exchanger mediates TNF-alpha induced hepatocyte apoptosis via the
calpain dependent degradation of
Bcl-xL
Zhu et al., Brain Behav Immun 2010
(Hypoxia-Ischemia, Brain) :
Nuclear translocation and
calpain dependent reduction of
Bcl-2 after neonatal cerebral hypoxia-ischemia
Zhao et al., Biochem Biophys Res Commun 2012
:
Lipopolysaccharide induces endothelial cell apoptosis via activation of Na(+)/H(+) exchanger 1 and
calpain dependent degradation of
Bcl-2
Dho et al., PLoS Biol 2013
:
Additionally, we show that degradation of deamidated
Bcl-xL is
mediated at least in part by
calpain
Ye et al., Can J Neurol Sci 2013
(Neurotoxicity Syndromes) :
Protection may be provided through a variety of effects, including the prevention of membrane depolarization, neuronal excitotoxicity and mitochondrial energy failure, increases in intracellular free calcium ( [ Ca2+ ] i ),
activation of
calpain , and reduction of
Bcl-2 levels
Eymin et al., Cancer Res 1997
(Leukemia) :
Both gadd153 mRNA level increase and internucleosomal DNA fragmentation were inhibited by N-tosyl-L-phenylalanine chloromethylketone, a serine threonine protease inhibitor, N-acetyl-leucyl-leucyl-norleucinal, an
inhibitor of
calpain , N-acetylcysteine, an inhibitor of oxidative metabolism, and overexpression of
Bcl-2