Gene interactions and pathways from curated databases and text-mining

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CASP5 — SP1

Text-mined interactions from Literome

Miyoshi et al., Biochem Biophys Res Commun 2005 : Experiments using a GC-specific DNA binding agent, mithramycin A, and an electrophoretic mobility shift assay demonstrated that Sp1 might mediate the enhanced expression of caspase-3
Sudhakar et al., FEBS J 2008 : The caspase-3 promoter was activated by Sp1 in Sp1-deficient Drosophila SL-2 cells
Kikuchi et al., J Biol Chem 2013 (Multiple Myeloma) : K-7174 induces transcriptional repression of class I histone deacetylases ( HDAC1, -2, and -3 ) via caspase-8 dependent degradation of Sp1 , the most potent transactivator of class I HDAC genes