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BMP1 — CASP6
Text-mined interactions from Literome
Merino et al., Ann N Y Acad Sci 1999
:
The
BMP proapoptotic activity requires the expression of members of the msx family of closely related homeobox containing genes and is finally
mediated by
caspase activation, but the nature of the caspase ( s ) directly responsible for the cell death is also unknown
Haÿ et al., J Biol Chem 2001
:
Consistent with these results,
BMP-2 increases
caspase-9 and caspase-3, -6, and -7 activity, and an anti-caspase-9 agent suppresses BMP-2 induced apoptosis
Mogi et al., J Biol Chem 2003
:
Surprisingly,
BMP-4 induced transient and potent activation of
caspase-8 , caspase-2, and caspase-3, in this order
Haÿ et al., J Biol Chem 2004
:
In contrast to SaOS2 cells, however,
BMP-2 or BMP-2 overexpression did not
increase caspase-9 and caspases-3, -6, and -7 activity and DNA fragmentation in OHS4 cells ... Consistently,
BMP-2 increased protein kinase C ( PKC ) activity, and PKC inhibition
suppressed BMP-2 induced
caspase activity in SaOS2 but not in OHS4 cells that lack BMP-RIB ... A dominant negative
BMP-RIB inhibited BMP-2 induced
caspase activity, whereas wild-type BMP-RIB promoted caspase activity induced by BMP-2 in SaOS2 and MC3T3-E1 cells
Saito et al., Anticancer Res 2003
(Carcinoma, Squamous Cell) :
The most cytotoxic
BMP activated
caspase-3 activity to the least extent, possibly in part due to the occurrence of necrosis
Lagna et al., Am J Physiol Lung Cell Mol Physiol 2006
(Hypertension, Pulmonary) :
BMP dependent activation of
caspase-9 and caspase-8 mediates apoptosis in pulmonary artery smooth muscle cells
Xia et al., J Pharmacol Exp Ther 2008
(MAP Kinase Signaling System) :
Lithium pretreatment dose-dependently reduced
PCP induced
caspase-3 activation and DNA fragmentation in layers II to IV of the cortex
Lei et al., J Neurochem 2009
(Neurotoxicity Syndromes) :
DHX pre-treatment of rat pups prior to PCP on postnatal days 7, 9 and 11 inhibited
PCP induced
caspase-3 activation on PN11 and deficits in pre-pulse inhibition of acoustic startle measured on PN 26-28