Gene interactions and pathways from curated databases and text-mining

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CASP7 — LYN

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Vasant et al., Free Radic Biol Med 2003 : Treatment of lymphocytes with Na [ Cr ( V ) O ( ehba ) ( 2 ) ] and K ( 2 ) Cr(2)O ( 7 ) leads to the activation of the Src-family protein tyrosine kinases namely, p56 ( lck ), p59 ( fyn ), and p56/53(lyn) , which then activates caspase-3 , both of which are under the partial influence of ROS
Ito et al., Eur J Haematol 2007 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Silencing of Lyn by short interfering RNA ( siRNA ) in MYL-R, but not in MYL, induced significant growth-inhibition, increased caspase-3 activity, and induced partial recovery from imatinib-resistance
Jia et al., J Biol Chem 2008 (Sepsis) : Thus the phosphorylation and dephosphorylation of caspase-8 , mediated by Lyn and SHP-1, respectively, represents a novel, dynamic post-translational mechanism for the regulation of neutrophil apoptosis whose dysregulation contributes to persistent neutrophil survival in sepsis
Gamas et al., Leukemia 2009 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : We established that Lyn is cleaved in imatinib treated parental K562 cells in a caspase dependent manner