◀ Back to CTNNB1
CBY1 — CTNNB1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
beta catenin (CTNNB1)
→
chibby (CBY1)
(modification, collaborate)
Takemaru et al., Nature 2003, Tian et al., Proc Natl Acad Sci U S A 2004, Li et al., J Cell Biol 2008, Mofunanya et al., BMC molecular biology 2009, Li et al., Mol Biol Cell 2010
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
beta catenin (CTNNB1)
→
14-3-3 family/chibby/beta catenin complex (YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB-CBY1-CTNNB1)
(modification, collaborate)
Takemaru et al., Nature 2003, Tian et al., Proc Natl Acad Sci U S A 2004, Li et al., J Cell Biol 2008, Mofunanya et al., BMC molecular biology 2009, Li et al., Mol Biol Cell 2010
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
chibby (CBY1)
→
14-3-3 family/chibby/beta catenin complex (YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB-CBY1-CTNNB1)
(modification, collaborate)
Takemaru et al., Nature 2003, Tian et al., Proc Natl Acad Sci U S A 2004, Li et al., J Cell Biol 2008, Mofunanya et al., BMC molecular biology 2009, Li et al., Mol Biol Cell 2010
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
14-3-3 family (YWHAH/YWHAZ/YWHAQ/SFN/YWHAE/YWHAG/YWHAB)
→
14-3-3 family/chibby/beta catenin complex (YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB-CBY1-CTNNB1)
(modification, collaborate)
Takemaru et al., Nature 2003, Tian et al., Proc Natl Acad Sci U S A 2004, Li et al., J Cell Biol 2008, Mofunanya et al., BMC molecular biology 2009, Li et al., Mol Biol Cell 2010
Evidence: mutant phenotype, physical interaction
-
Reactome Reaction:
CBY1
→
CTNNB1
(reaction)
Takemaru et al., Nature 2003, Li et al., J Cell Biol 2008, Voronina et al., J Cell Biol 2009*, Li et al., Mol Biol Cell 2010
-
Reactome Reaction:
CBY1
→
CTNNB1
(direct_complex)
Takemaru et al., Nature 2003, Li et al., J Cell Biol 2008, Voronina et al., J Cell Biol 2009*, Li et al., Mol Biol Cell 2010
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
CBY1
—
CTNNB1
(physical association, affinity chromatography technology)
Vandepoele et al., Exp Cell Res 2010*
-
IRef Biogrid Interaction:
CBY1
—
CTNNB1
(direct interaction, pull down)
Takemaru et al., Nature 2003
-
IRef Biogrid Interaction:
CBY1
—
CTNNB1
(physical association, affinity chromatography technology)
Takemaru et al., Nature 2003
-
IRef Dip Interaction:
CBY1
—
CTNNB1
(direct interaction, pull down)
Xing et al., Structure 2008*
-
IRef Hprd Interaction:
CBY1
—
CTNNB1
(in vitro)
Takemaru et al., Nature 2003
-
IRef Hprd Interaction:
CBY1
—
CTNNB1
(in vivo)
Takemaru et al., Nature 2003
-
IRef Ophid Interaction:
CBY1
—
CTNNB1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Takemaru et al., Cell cycle (Georgetown, Tex.) 2009
:
Our recent study revealed a second mechanism for
Cby mediated
beta-catenin inhibition in which Cby cooperates with 14-3-3 adaptor proteins to facilitate nuclear export of beta-catenin, following phosphorylation of Cby by Akt kinase
Mofunanya et al., BMC molecular biology 2009
:
Although monomeric
Cby is
sufficient to bind to
beta-catenin and block beta-catenin mediated transcriptional activation, homodimer formation of Cby is indispensable for its efficient nuclear import