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CCL2 — PTGS2

Text-mined interactions from Literome

Futagami et al., Gut 2003 (Gastritis...) : Monocyte chemoattractant protein 1 ( MCP-1 ) released from Helicobacter pylori stimulated gastric epithelial cells induces cyclooxygenase 2 expression and activation in T cells
Tanaka et al., Gut 2006 (Adenoma...) : MCP-1 stimulated COX-2 expression and PGE ( 2 ) and VEGF release in human macrophages ... Addition of exogenous PGE ( 2 ) reversed this inhibitory effect on VEGF release, suggesting that MCP-1 in adenoma epithelial cells might be involved in COX-2 expression and subsequent macrophage activation ... MCP-1 in colorectal adenoma epithelial cells might be involved in macrophage migration and COX-2 expression, leading to the subsequent development of colonic adenoma
Chen et al., Eur J Pharmacol 2006 : We show that dipyridamole inhibited interleukin-6 and monocyte chemoattractant protein-1 secretion, inducible nitric oxide synthase protein expression, nitrite accumulation, and cyclooxygenase-2 (COX-2) induction in lipopolysaccharide (LPS) activated RAW 264.7 macrophages
Futagami et al., Prostaglandins Leukot Essent Fatty Acids 2008 (Stomach Neoplasms) : COX-2 and CCR2 induced by CD40 ligand and MCP-1 are linked to VEGF production in endothelial cells ... The aim of this study was to examine the effect of MCP-1/CCR2 and CD40-CD40L interaction on COX-2 and VEGF expression in endothelial cells ... MCP-1 had a synergistic effect on COX-2 , CCR2 and VEGF levels in CD40L stimulated HUVECs
Futagami et al., J Gastroenterol 2008 (Adenocarcinoma...) : MCP-1 and CD40L had a synergistic effect on COX-2 expression and subsequent VEGF production in gastric cancer
Wong et al., Arterioscler Thromb Vasc Biol 2011 (Atherosclerosis...) : The present study pinpoints a novel role of PKCd in Ang II-induced endothelial COX-2 upregulation and identifies a COX-2 dependent proatherosclerotic cytokine monocyte chemoattractant protein-1
Pflücke et al., J Pain 2013 (Hyperalgesia) : In vitro CCL2 did not directly stimulate Cox-2 expression or prostaglandin E2 formation but slightly enhanced the formation of reactive oxygen species in monocytes and macrophages