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CCL2 — SMAD3

Text-mined interactions from Literome

Feinberg et al., Circ Res 2004 (Hyperplasia...) : Essential role for Smad3 in regulating MCP-1 expression and vascular inflammation ... Adenoviral overexpression of Smad3 potently repressed inducible expression of endogenous MCP-1
Kim et al., Circ Res 2008 (Atherosclerosis...) : Decreased monocyte chemoattractant protein-1 expression induced by PPARdelta was mediated by the effector of TGF-beta1, Smad3
Zhang et al., J Biol Chem 2009 (Hyperplasia) : In the rat carotid injury model, Smad3 overexpression significantly increased MCP-1 expression after vascular injury, consistent with our in vitro results ... Interestingly, TGF-beta/Smad3 induced MCP-1 was completely blocked by both Ro-32-0432 and rotterlin, suggesting protein kinase C-delta (PKCdelta) may play a role in TGF-beta/Smad3 induced MCP-1 expression
Fang et al., J Biol Chem 2012 (Breast Neoplasms...) : RNA interference of CCR2 expression in breast cancer cells significantly inhibited CCL2 induced migration, survival, and phosphorylation of Smad3 and p42/44MAPK proteins ... Furthermore, we show that CCL2 induced Smad3 signaling through MEK-p42/44MAPK regulates expression and activity of Rho GTPase to mediate CCL2 induced breast cancer cell motility and survival