Gene interactions and pathways from curated databases and text-mining

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CCL2 — CCL8

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Struyf et al., Eur J Immunol 2009 (Neoplasms) : MCP-2/CCL8 ( 6-75 ) induced internalization of CCR2, inhibited MCP-1/CCL2 and MCP-2/CCL8 ERK signaling and antagonized the chemotactic activity of several CCR2 ligands ( MCP-1/CCL2, MCP-2/CCL8, MCP-3/CCL7 )
Shah et al., Pediatr Res 2010 (Chorioamnionitis...) : MCP-1 and MCP-2 were not induced in liver or chorioamnion, but MCP-1 increased in cord plasma
Van Damme et al., J Immunol 1994 : It remains to be studied under which pathological conditions MCP-2 is released in vivo and whether MCP-1 and MCP-2 can activate different target cells
Moore et al., J Leukoc Biol 1997 : In competition studies MCP-1, MCP-2 , and MCP-3 completely inhibited 125I labeled MCP-1 binding with Ki values of 0.3 ( 0.16-0.46 ), 8.8 ( 3.4-26 ), and 12.2 ( 0.6-22 ) nM, respectively ... In calcium mobilization studies, MCP-1 and MCP-3 induced robust elevations in intracellular calcium concentrations, whereas MCP-2 was only weakly active