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CCL2 — CCL8
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Struyf et al., Eur J Immunol 2009
(Neoplasms) :
MCP-2/CCL8 ( 6-75 ) induced internalization of CCR2,
inhibited MCP-1/CCL2 and MCP-2/CCL8 ERK signaling and antagonized the chemotactic activity of several CCR2 ligands ( MCP-1/CCL2, MCP-2/CCL8, MCP-3/CCL7 )
Shah et al., Pediatr Res 2010
(Chorioamnionitis...) :
MCP-1 and
MCP-2 were not induced in liver or chorioamnion, but
MCP-1 increased in cord plasma
Van Damme et al., J Immunol 1994
:
It remains to be studied under which pathological conditions
MCP-2 is released in vivo and whether
MCP-1 and MCP-2 can
activate different target cells
Moore et al., J Leukoc Biol 1997
:
In competition studies MCP-1,
MCP-2 , and MCP-3 completely
inhibited 125I labeled
MCP-1 binding with Ki values of 0.3 ( 0.16-0.46 ), 8.8 ( 3.4-26 ), and 12.2 ( 0.6-22 ) nM, respectively ... In calcium mobilization studies,
MCP-1 and MCP-3
induced robust elevations in intracellular calcium concentrations, whereas
MCP-2 was only weakly active