Gene interactions and pathways from curated databases and text-mining

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CCND1 — MUC1

Text-mined interactions from Literome

Huang et al., Cancer Biol Ther 2003 : We also show that transcription of the Wnt responsive cyclin D1 promoter is activated by MUC1 , but not MUC1 ( Y46F ), and that the cyclin D1 gene is upregulated in MUC1 positive cells
Rajabi et al., J Biol Chem 2012 (Breast Neoplasms) : Silencing MUC1-C in human breast cancer cells down-regulated activation of the cyclin D1 promoter and decreased cyclin D1 expression ... In addition, a MUC1-C inhibitor blocked the interaction with TCF7L2 and suppressed cyclin D1 levels ... These findings indicate that the MUC1-C oncoprotein contributes to TCF7L2 activation and thereby promotes cyclin D1 expression in breast cancer cells