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CCND1 — MUC1
Text-mined interactions from Literome
Huang et al., Cancer Biol Ther 2003
:
We also show that transcription of the Wnt responsive
cyclin D1 promoter is
activated by
MUC1 , but not MUC1 ( Y46F ), and that the cyclin D1 gene is upregulated in MUC1 positive cells
Rajabi et al., J Biol Chem 2012
(Breast Neoplasms) :
Silencing
MUC1-C in human breast cancer cells
down-regulated activation of the
cyclin D1 promoter and decreased cyclin D1 expression ... In addition, a
MUC1-C inhibitor blocked the interaction with TCF7L2 and
suppressed cyclin D1 levels ... These findings indicate that the
MUC1-C oncoprotein contributes to TCF7L2 activation and thereby
promotes cyclin D1 expression in breast cancer cells