Gene interactions and pathways from curated databases and text-mining

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CD14 — IL4

Text-mined interactions from Literome

Iwagaki et al., Infect Immun 2000 : The purpose of this study was to compare and contrast the endotoxin neutralizing activities of two synthetic antiendotoxin peptides ( SAEP-2 and SAEP-4 ), PMB, and an LPS core-specific monoclonal antibody ( MAb ), WN1 222-5, based on their abilities to inhibit CD14 mediated target cell uptake of fluorescein isothiocyanate ( FITC ) -conjugated LPS, detected by flow cytometry and confocal microscopy, and LPS induced production of the proinflammatory cytokines, interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha), as measured by bioassays
Roth et al., Cancer Res 2000 (Neoplasms) : Granulocyte macrophage colony stimulating factor and interleukin 4 enhance the number and antigen presenting activity of circulating CD14+ and CD83+ cells in cancer patients
Liu et al., Pediatr Res 2001 : Neonates are relatively immature in their immune response ; thus, to further clarify the differences of monocyte function and differentiation between neonates and adults, we investigated their CD14 ( + ) CD4 ( + ) and CD14 ( + ) CD16 ( + ) monocyte subpopulations, production of IL-1beta and tumor necrosis factor-alpha induced by lipopolysaccharide, and their CD14 and CD1a phenotypic changes in response to IL-4 and granulocyte-macrophage colony stimulating factor ... Down-regulation of CD14 expression in response to IL-4 and GM-CSF was slower in cord blood monocytes than that in adult peripheral blood monocytes
Mizuno et al., J Leukoc Biol 2001 : MGCs were not produced from CD14 ( + ) /CD16 ( + ) monocytes or immature dendritic cells induced by granulocyte macrophage-colony stimulating factor ( GM-CSF ) and interleukin (IL) 4 and only weakly produced from macrophage (M)-CSF- or GM-CSF induced macrophages
Pilette et al., Eur Respir J 2002 : However, several observations suggested that IL-9 and IL-4 act through different mechanisms : 1 ) interferon-gamma antagonised the IL4- but not the IL-9 mediated inhibition of AM oxidative burst ; 2 ) expression of CD14 was downregulated by IL-4 but not by IL-9 and 3 ) production of tumour growth factor-beta by activated AM was potentiated by IL-9 and not by IL4 , and was required for the IL-9 mediated inhibition of AM oxidative burst
Lauener et al., Eur J Immunol 1990 : Nuclear run-off assays revealed that the IL4 dependent down-regulation of CD14 resulted from decreased transcription
Ruppert et al., Immunobiology 1991 : In this study we compared the effects of the cytokines IL-1, IL-6, IL-4 , and a combination of IL-1 and IL-6 on the expression of the CD14 antigen , the FcIIIg receptor molecule CD16 and the MHC-class II molecules HLA-DR and HLA-DP
Jansen et al., Lymphokine Cytokine Res 1991 (Acute Disease...) : Since ( autocrine ) IL-6 is possibly involved in the proliferation and differentiation of acute myeloid leukemia cells with myelomonocytic differentiation ( AML-M4/M5 ), we studied the effects of IL-4 on IL-6 production and CD14 expression by these cells
Sun et al., Curr Mol Med 2012 (Chronic Disease...) : However, in the presence of IL-4 or IL10, CD14 ( + ) CD16 ( - ) monocytes of HIV infected patients produced more TNF-a, IL-6, IL-12 or Il-1ß after IFN-?/LPS stimulation than the healthy control, supporting the impaired IL-4R and IL-10R signal pathways in patients with LTNP and CHI. Therefore, our present study offered the basic information for the Th1/Th2 cytokine receptor expression and function on monocyte subsets in untreated HIV infected individuals
Quentmeier et al., Leukemia 1994 (Leukemia, Monocytic, Acute) : IL-4 inhibits the LPS induced expression of CD14 and monocyte-specific esterase mRNA in MONO-MAC-6 cells ... However, upregulation of CD14 and MSE mRNA expression in the cell line by a 2-day incubation with LPS were inhibited by IL-4
Hart et al., J Leukoc Biol 1995 : Seven-day cultured monocytes/macrophages showed ( 1 ) diminished TNF-alpha production in response to IL-10 but not IL-4 ( 2 ), diminished IL-1 beta production in response to both IL-4 and IL-10, and compared with fresh monocytes ( 3 ), diminished CD14 expression in response to IL-4 , and ( 4 ) a lesser increase in CD23 expression in response to IL-4
Ruppert et al., Adv Exp Med Biol 1993 : IL-4 induces down-regulation of CD14 expression on human monocytes only when the cells are cultured with serum ... Instead of serum, GM-CSF was required as a co-factor to restore the regulatory effect of IL-4 on CD14-expression
Garin et al., Int J Immunopharmacol 1996 : We found that HLA-DR, HLA-DQ, CD14 and CD23 were differentially regulated by biostim and IL-4 or IL-13
Becher et al., J Neurosci Res 1996 : Surface CD14 expression can be down-regulated by interaction with its ligand lipopolysaccharide (LPS), and by the T-helper ( Th1 ) cytokine interferon-gamma (IFN-gamma) or the Th2 cytokine interleukin-4 (IL-4)
Quentmeier et al., Immunology 1996 : Paralleling the situation in peripheral blood monocytes ( PBMo ), recombinant human interleukin-4 (IL-4) down-regulated the expression of CD14 on the cell surface of MUTZ-3, but not that of MONO-MAC-6 cells
Heidenreich et al., J Immunol 1997 : The effects of LPS and IL-4 on the expression of CD14 , indicated by binding of Leu M3 Ab, and PCD of monocytes were studied simultaneously and in a kinetic fashion by multiparameter flow cytometry
Canque et al., J Leukoc Biol 1998 : IL-4 and CD40 ligation affect differently the differentiation, maturation, and function of human CD34+ cell derived CD1a+CD14- and CD1a-CD14+ dendritic cell precursors in vitro ... Thus, IL-4 or CD40 ligation induced CD1a+CD14- and CD1a-CD14+ DC precursors to differentiate into phenotypically close but functionally different DC populations, suggesting that DC function is primarily determined by their origin