Matsumoto et al., J Exp Med 2003
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Committed T helper ( Th ) 2 cells exclusively expressed SOCS3 and production of Th2 cytokines, such as IL-4 and IL-5, was much less dependent on CD28 costimulation compared with interferon gamma and IL-2 production in Th1 cells
Owaki et al., J Immunol 2006
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Similar inhibition of CD28 mediated IL-2 production and augmentation of SOCS3 expression by IL-27 were observed in a T cell hybridoma cell line, 2B4
Orabona et al., Proc Natl Acad Sci U S A 2008
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We found that SOCS3-known to interact with phosphotyrosine containing peptides and be selectively induced by CD28-Ig/IL-6-would bind IDO and target the IDO/SOCS3 complex for ubiquitination and subsequent proteasomal degradation