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CD4 — IL1B

Text-mined interactions from Literome

Banda et al., J Immunol 2003 (Arthritis, Experimental) : The production of IFN-gamma, TNF-alpha, and IL-1beta in cultured spleen cells was reduced by in vivo treatment with low dose, but not high dose, mIL-18BP. FACS analysis showed a slight decrease in NK cells and an increase in CD4 ( + ) T cells in spleens of mice treated with mIL-18BP
O'Sullivan et al., J Immunol 2006 (Diabetes Mellitus, Type 1...) : IL-1beta drives proliferation and cytokine production by CD4 ( + ) CD25 ( + ) FoxP3 ( - ) effector/memory T cells, attenuates CD4 ( + ) CD25 ( + ) FoxP3 ( + ) regulatory T cell function, and allows escape of CD4 ( + ) CD25 ( - ) autoreactive effectors from suppression
Lyakh et al., Immunol Rev 2008 : IL-23, IL-6, transforming growth factor ( TGF-beta1 ), and IL-1beta in supernatants from activated human DCs induce human naive CD4 ( + ) T cells to produce IL-17
Ben-Sasson et al., Proc Natl Acad Sci U S A 2009 : These results indicate that IL-1beta signaling in T cells markedly induces robust and durable primary and secondary CD4 responses
Wang et al., Exp Cell Res 2010 : Moreover, the inflammatory cytokine IL-1beta , either exogenously added or produced by CD14 ( + ) monocytes in culture, could trigger expression of high levels of PGE ( 2 ) by hUC-MSCs, whereas inclusion of the IL-1 receptor antagonist (IL-1RA) in the culture down-regulated not only PGE ( 2 ) expression, but also reversed the promotional effect of CD14 ( + ) monocytes and partially restored CD4 ( + ) and CD8 ( + ) T cell proliferation and IFN-gamma secretion