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CD40 — PTK2
Text-mined interactions from Literome
Suttles et al., J Biol Chem 1999
:
CD40 mediated activation of
protein tyrosine kinase activity and subsequent inflammatory cytokine production are abrogated by treatment of monocytes with the T helper type 2 cytokines interleukin 4 (IL-4) and interleukin 10 (IL-10)
NĂ©ron et al., Int Immunol 2006
:
B cell proliferation following
CD40 stimulation results in the expression and
activation of Src
protein tyrosine kinase
Ren et al., J Exp Med 1994
:
These results suggest that lyn plays an important role in
CD40 mediated
PTK activation and identify PLC gamma 2 and PI-3-kinase targets for CD40 mediated phosphorylation, suggesting a role for these two enzymes in CD40 signal transduction
Ren et al., Immunol Invest 1994
:
Direct evidence for
CD40 mediated
PTK activation was demonstrated by increased tyrosine phosphorylation as detected by anti-phosphotyrosine Western blots of cell lysates prepared from dense resting tonsil B cells stimulated with biotinylated anti-CD40 monoclonal antibody plus avidin ... CD40 mediated PKC translocation was dependent on PTK activation, whereas
PTK activity
induced by
CD40 ligation was independent of PKC activity, suggesting that PTK activation precedes PKC activation in resting B cells stimulated with anti-CD40 mAb
Worm et al., Eur J Immunol 1995
:
Induction of LT alpha mRNA and surface expression by
CD40 ligation is
inhibited by the
protein tyrosine kinase ( PTK ) inhibitors herbimycin and genistein in a dose dependent manner
Suttles et al., J Leukoc Biol 1996
:
T cell rescue of monocytes from apoptosis : role of the CD40-CD40L interaction and requirement for
CD40 mediated induction of
protein tyrosine kinase activity
Poe et al., J Immunol 1997
:
Together these results suggest that in monocytes 1 ) both IL-4 and IL-10 target
CD40 induced
PTK activity in the down-regulation of IL-1beta synthesis ; and 2 ) IL-4 and IL-10 have divergent effects on the CD40 signaling pathway, in that these cytokines are synergistic with respect to their abilities to inhibit CD40 mediated IL-1beta synthesis and differ in their abilities to block CD40 mediated rescue from apoptosis