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CD44 — CDH1
Text-mined interactions from Literome
Xu et al., J Biol Chem 2003
(Neoplasm Invasiveness) :
E-cadherin negatively
regulates CD44-hyaluronan interaction and CD44 mediated tumor invasion and branching morphogenesis ... The results reported here demonstrated for the first time that
E-cadherin negatively
regulated CD44-HA interaction and CD44 function and suggested that balanced function of CD44 and E-cadherin may be essential for normal epithelial cell functions, and imbalanced up-regulation of CD44 function and/or down-regulation of E-cadherin function likely contributes to tumor progression
Wang et al., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2004
(Lymphatic Metastasis...) :
In the group of nasopharyngeal carcinoma with distant metastasis, the expression of
E-cadherin and nm23H1 also increased and the expression of
CD44H , MMP-3 and VEGF all
increased
Bao et al., J Cell Biochem 2011
(Pancreatic Neoplasms) :
Moreover, over-expression of FoxM1 led to the acquisition of EMT phenotype by
activation of mesenchymal cell markers, ZEB1, ZEB2, Snail2,
E-cadherin , and vimentin, which is consistent with increased sphere forming ( pancreatospheres ) capacity and expression of CSC surface markers (
CD44 and EpCAM )