Gene interactions and pathways from curated databases and text-mining

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CD44 — RAC1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Bourguignon et al., J Biol Chem 2000 (Breast Neoplasms) : Most importantly, the binding of HA to CD44v3 of SP1 cells stimulates Tiam1 catalyzed Rac1 signaling and cytoskeleton mediated tumor cell migration
Bourguignon et al., J Biol Chem 2004 (Calcium Signaling) : The binding of HA to CD44 induces PKNgamma association with endogenous Rac1 and its activity in keratinocytes
Bourguignon et al., J Neurochem 2007 : Hyaluronan-CD44 interaction stimulates Rac1 signaling and PKN gamma kinase activation leading to cytoskeleton function and cell migration in astrocytes