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CDC42 — CXCL12

Pathways - manually collected, often from reviews:

• NCI Pathway Database CXCR4-mediated signaling events: RAC1-CDC42/GDP complex (RAC1_CDC42) → SDF1/CXCR4/VAV1 complex (CXCL12-CXCR4-VAV1) (modification, collaborate)
  Vicente-Manzanares et al., Blood 2005, García-Bernal et al., Mol Biol Cell 2005
  Evidence: mutant phenotype, assay

Text-mined interactions from Literome

Haddad et al., Blood 2001 (Wiskott-Aldrich Syndrome) : We provide here direct evidence that SDF-1 activates Cdc42
Soede et al., J Immunol 2001 : Stromal cell derived factor-1 induced LFA-1 activation during in vivo migration of T cell hybridoma cells requires Gq/11, RhoA, and myosin, as well as Gi and Cdc42
Bartolomé et al., Cancer Res 2004 (Lymphatic Metastasis...) : Moreover, SDF-1alpha triggered the activation of the GTPases RhoA, Rac1, and Cdc42 on BLM cells, and expression of dominant negative forms of RhoA and Rac1, but not Cdc42 , substantially impaired the invasion of transfectants in response to SDF-1alpha, as well as the increase in MT1-MMP expression
Takesono et al., Curr Biol 2004 : Expression of a dominant negative Itk impaired SDF-1alpha induced migration, cell polarization, and activation of Rac and Cdc42
Chang et al., Oncogene 2009 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : We found that SDF-1alpha stimulated Cdc42 GTPase activation in myeloid progenitor 32D, but not in p210 ( Bcr-Abl ) -transformed ( 32Dp210 ) cells ... Inhibition of p210 ( Bcr-Abl ) kinase activity decreased basal Cdc42 activity and restored SDF-1alpha induced Cdc42 and migration responses