Gene interactions and pathways from curated databases and text-mining

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CDC6 — TCF19

Text-mined interactions from Literome

Meimoun et al., Mol Biol Cell 2000 : Here we report that SCF ( CDC4 ), a recently characterized protein complex that acts in conjunction with the ubiquitin conjugating enzyme Cdc34 to degrade cell cycle regulators, is also necessary for the degradation of the transcription factor Gcn4. Degradation of Gcn4 occurs throughout the cell cycle, whereas degradation of the known cell cycle substrates of Cdc34/SCF(CDC4) is cell cycle regulated
Chen et al., BMC systems biology 2009 : The regulated action for four selected cytokinesis related genes ( BUD4, CHS2, IQG1, and CDC5 ) belongs to the M-phase or M/G1 phase, consistent with the empirical observations that in S. cerevisiae, the Mcm1-Ndd1-Fkh2 transcription factor complex can regulate expression of the cytokinesis related genes BUD4, CHS2, IQG1, and CDC5
Acosta et al., Mol Biol Cell 2011 : In contrast, CDC5 overexpression leads to premature induction of the Ndt80 transcription factor , which drives the expression of genes required for meiotic divisions, including CLB1
Cross et al., Mol Cell Biol 1994 : It has been proposed that positive feedback operates via Cln/Cdc28 activation of the Swi4/Swi6 transcription factor , leading to CLN1 and CLN2 transcription due to Swi4 binding to specific sites ( SCBs ) in the CLN1 and CLN2 promoters