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CDCA3 — JUN

Text-mined interactions from Literome

Li et al., Hepatology 2006 : IL-1 beta and CDCA reduced CYP7A1 but induced c-Jun messenger RNA expression in human primary hepatocytes ... In conclusion, IL-1 beta and CDCA inhibit HNF4 alpha but induce c-Jun , which in turn blocks HNF 4 alpha recruitment of PGC-1 alpha to the CYP7A1 chromatin and results in inhibition of CYP7A1 gene transcription
Su et al., Respirology 2013 : CDCA induced significant p38 and c-Jun N-terminal kinase (JNK) phosphorylation, cytosolic phospholipase A2 (cPLA2 ) and cyclooxygenase-2 (COX-2) messenger RNA expression, PGE2 production, TER reduction and decay of JP ( including occludin, zonula occludens-1 ( ZO-1 ) and E-cadherin, in which ZO-1 had maximal change )