Medici et al., Mol Biol Cell 2006
:
However, our results also demonstrate that a complete loss of E-cadherin and transformation to the mesenchymal phenotype are dependent on Smad signaling, which subsequently stimulates formation of beta-catenin/LEF-1 complexes that induce EMT
Wang et al., J Orthop Res 2012
:
We found that E-cadherin induces the expression of BMP-4 and BMP-7 genes and enhances Smad1/5 phosphorylation
Helbing et al., J Pathol 2013
(Lung Injury) :
BMP2 is up-regulated after epithelial injury and causes epithelial dysfunction and hyperpermeability, mediated by the Smad1/5-Id1 dependent down-regulation of E-cadherin