Gene interactions and pathways from curated databases and text-mining

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CDK9 — RB1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Kourea et al., Am J Pathol 1999 (Cell Transformation, Neoplastic...) : In this study, we investigated patterns of expression of p53 and pRB , cyclin dependent kinase inhibitors ( CKIs ) p21 and p27, as well as cyclins D1 and E, in a cohort of 35 well characterized MPNSTs and 16 NFs
Kuo et al., Cancer Lett 2006 (Glioma...) : After treatment with CAPE ( 50 microM ) for 6h, it demonstrated that the protein level of hyperphosphorylated pRb decreased, and cyclin dependent kinase inhibitors p21, p27, and p16 were marked up-regulated
Magenta et al., Mol Cell Biol 2008 : While the role of cyclin/cyclin dependent kinase complexes in the modulation of pRb phosphorylation has been extensively studied, relatively little is known about the molecular mechanisms regulating phosphate removal by phosphatases
Kratzke et al., Cancer Res 1996 (Adenocarcinoma...) : These findings establish the prognostic significance ( of the absence of p16INK4, in resected NSCLC and confirm the critical importance of disrupting the pathway of cyclin dependent kinase mediated phosphorylation of pRB in the molecular oncogenesis and progression of NSCLC