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CDK9 — RB1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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IRef Biogrid Interaction:
CDK9
—
RB1
(direct interaction, enzymatic study)
De Luca et al., J Cell Physiol 1997*
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IRef Biogrid Interaction:
CDK9
—
RB1
(direct interaction, enzymatic study)
Graña et al., Proc Natl Acad Sci U S A 1994*
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IRef Biogrid Interaction:
CDK9
—
RB1
(direct interaction, enzymatic study)
Garriga et al., Biochem J 1996*
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IRef Biogrid Interaction:
CDK9
—
RB1
(colocalization, biochemical)
Garriga et al., Biochem J 1996*
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IRef Biogrid Interaction:
CDK9
—
RB1
(physical association, affinity chromatography technology)
Simone et al., Oncogene 2002*
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IRef Biogrid Interaction:
CDK9
—
RB1
(direct interaction, pull down)
Simone et al., Oncogene 2002*
-
IRef Hprd Interaction:
CDK9
—
RB1
(in vitro)
Graña et al., Proc Natl Acad Sci U S A 1994*, Garriga et al., Biochem J 1996*, De Luca et al., J Cell Physiol 1997*
Text-mined interactions from Literome
Kourea et al., Am J Pathol 1999
(Cell Transformation, Neoplastic...) :
In this study, we investigated patterns of expression of p53 and
pRB ,
cyclin dependent kinase inhibitors ( CKIs ) p21 and p27, as well as cyclins D1 and E, in a cohort of 35 well characterized MPNSTs and 16 NFs
Kuo et al., Cancer Lett 2006
(Glioma...) :
After treatment with CAPE ( 50 microM ) for 6h, it demonstrated that the protein level of hyperphosphorylated
pRb decreased, and
cyclin dependent kinase inhibitors p21, p27, and p16 were marked
up-regulated
Magenta et al., Mol Cell Biol 2008
:
While the
role of
cyclin/cyclin dependent kinase complexes in the modulation of
pRb phosphorylation has been extensively studied, relatively little is known about the molecular mechanisms regulating phosphate removal by phosphatases
Kratzke et al., Cancer Res 1996
(Adenocarcinoma...) :
These findings establish the prognostic significance ( of the absence of p16INK4, in resected NSCLC and confirm the critical importance of disrupting the pathway of
cyclin dependent kinase mediated phosphorylation of
pRB in the molecular oncogenesis and progression of NSCLC