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CDC42 — CDKN1A
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Dharmawardhane et al., Mol Biol Cell 2000
:
p21 activated kinases (PAKs) are
targets for activated Rac and
Cdc42 guanosine 5'-triphosphatases and have been shown to regulate the actin-myosin cytoskeleton
Bao et al., Mol Cell Biol 2002
:
Concomitant with our finding that the small GTPases Cdc42 and Rac1 were activated by attachment to FN, constitutively active ( ca )
Cdc42 and ca Rac1
promoted down-regulation of
p21 ( CIP1 ) ... However, dominant negative ( dn )
Cdc42 and dn Rac1 mutants
blocked the anchorage induced degradation of
p21 ( CIP1 ), suggesting that an integrin induced Cdc42/Rac1 signaling pathway activates proteasomal degradation of p21 ( CIP1 )
Vidal et al., Blood 2002
:
Cdc42/Rac1 dependent activation of the
p21 activated kinase (PAK) regulates human platelet lamellipodia spreading : implication of the cortical-actin binding protein cortactin
Li et al., Gene regulation and systems biology 2008
:
Of the five genes tested by quantitative RT-PCR,
CDKN1A ( p21 ( waf1 ) ) was up
regulated ,
CDC2/cdk1 , MCM6, ORC1L were down regulated, while ORC3L expression remained unchanged following butyrate treatment
Malecka et al., J Biol Chem 2013
:
Autoinhibited
p21 activated kinase 1 (Pak1) can be
activated in vitro by the plasma membrane bound Rho GTPases Rac1 and
Cdc42 as well as by the lipid phosphatidylinositol ( 4,5 ) -bisphosphate ( PIP2 )