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CDKN1A — RHOA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Danesh et al., Proc Natl Acad Sci U S A 2002
(Diabetic Nephropathies) :
Immunofluorescence microscopy revealed that the overexpression of the dominant negative
RhoA led to a significant increase in
p21 expression
Adnane et al., Mol Cell Biol 1998
(Pancreatic Neoplasms) :
To identify the geranylgeranylated protein ( s ) involved in p21 ( WAF1/CIP1 ) transcriptional activation, we analyzed the
effects of the small GTPases Rac1 and
RhoA on
p21 ( WAF1/CIP1 ) promoter activity ... In contrast, constitutively active
RhoA repressed
p21 ( WAF1/CIP1 )
Auer et al., Biochem J 1998
:
Inhibition of
RhoA GTPase function
increased the basal expression of
p21Cip-1/WAF1 and p27Kip-1 but not p16INK4a, and enhanced the ability of MAPK signalling to decrease DNA synthesis