Gene interactions and pathways from curated databases and text-mining

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CDKN1A — RHOA

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Danesh et al., Proc Natl Acad Sci U S A 2002 (Diabetic Nephropathies) : Immunofluorescence microscopy revealed that the overexpression of the dominant negative RhoA led to a significant increase in p21 expression
Adnane et al., Mol Cell Biol 1998 (Pancreatic Neoplasms) : To identify the geranylgeranylated protein ( s ) involved in p21 ( WAF1/CIP1 ) transcriptional activation, we analyzed the effects of the small GTPases Rac1 and RhoA on p21 ( WAF1/CIP1 ) promoter activity ... In contrast, constitutively active RhoA repressed p21 ( WAF1/CIP1 )
Auer et al., Biochem J 1998 : Inhibition of RhoA GTPase function increased the basal expression of p21Cip-1/WAF1 and p27Kip-1 but not p16INK4a, and enhanced the ability of MAPK signalling to decrease DNA synthesis