Li et al., J Biol Chem 2005
:
Down-regulation of DNA-PK ( cs ) by either siRNA or a chemical inhibitor attenuated radiation induced Chk2 phosphorylation
RodrÃguez-Bravo et al., Cancer Res 2006
:
Neither wortmannin, Ly294002, nor SB202190 abrogated the caffeine-insensitive checkpoint response, indicating that DNA-PK and p38 alpha, beta are not involved in the ATR/ATM independent Chk1 activation upon DNA synthesis inhibition
Solier et al., Mol Cell Biol 2009
:
H2AX phosphorylation was dependent on DNA-PK, while Chk2 phosphorylation was dependent on both ATM and DNA-PK