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CNTNAP1 — RHO

Text-mined interactions from Literome

Wolf et al., Genes Dev 2003 (Brain Neoplasms...) : Using a cell culture model of autocrine loop PDGF stimulation, we show that reduced Rho activity via p190RhoGAP overexpression or Rho kinase inhibition induced cellular process extension, a block in proliferation, and reduced expression of the neural precursor marker nestin
Hernández et al., Curr Biol 2004 : We find that Arg can stimulate p190RhoGAP to inhibit Rho and that Arg mediated phosphorylation is required for this stimulation
Wildenberg et al., Cell 2006 : We propose that Rac activation links diverse signaling systems to AJ assembly by controlling transient p190RhoGAP interactions with p120 and localized inhibition of Rho
Su et al., Exp Cell Res 2009 (Breast Neoplasms) : p190RhoGAP negatively regulates Rho activity at the cleavage furrow of mitotic cells ... Quantified data revealed that in contrast to ECT2 and dominate negative p190 ( Y1283Ap190 ), which resulted in hyper activated Rho, Rho activity in the CF was reduced by wild type p190 in a dose dependent manner
Ludwig et al., Genes & cancer 2011 : We show that the predominant phenotype of p190 overexpression in a variety of cell lines is apoptosis, which is mediated through p190 's regulation of Rho and caspases
Zebda et al., J Biol Chem 2013 : One mechanism involves p120 catenin interaction with Rho GTPase activating protein ( p190RhoGAP ), leading to p190RhoGAP recruitment to cell periphery and local inhibition of Rho activity