◀ Back to CDKN1B
CDKN1B — COPS5
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
CDKN1B
→
COPS5
(decreases)
Hwang et al., Oncogene 2004*
Evidence: Jab1 was also identified as a direct negative regulator of the CDK inhibitor, p27Kip1, resulting in cell cycle progression (Tomoda et al., 1999).
-
OpenBEL Selventa BEL large corpus:
CDKN1B
→
COPS5
(decreases)
Hwang et al., Oncogene 2004*
Evidence: Jun activation domain-binding protein 1 (Jab1) was originally identified as a coactivator of activator protein 1 (AP1) transcription and was also shown to promote degradation of the cyclin-dependent kinase inhibitor, p27Kip1.
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind_translation Interaction:
COPS5
—
CDKN1B
(experimental interaction detection)
Yang et al., Oncogene 2005*
-
IRef Biogrid Interaction:
COPS5
—
CDKN1B
(physical association, affinity chromatography technology)
Hsieh et al., Mol Cancer Res 2007*
-
IRef Biogrid Interaction:
COPS5
—
CDKN1B
(physical association, affinity chromatography technology)
Hwang et al., Oncogene 2004*
-
IRef Biogrid Interaction:
COPS5
—
CDKN1B
(physical association, affinity chromatography technology)
Pan et al., Cancer Res 2012*
-
IRef Biogrid Interaction:
COPS5
—
CDKN1B
(physical association, affinity chromatography technology)
Wang et al., Cancer Biol Ther 2008*
-
IRef Biogrid Interaction:
COPS5
—
CDKN1B
(physical association, affinity chromatography technology)
Caballero et al., Oncogene 2002*
-
IRef Biogrid Interaction:
COPS5
—
CDKN1B
(direct interaction, pull down)
Kouvaraki et al., Cancer Res 2006*
-
IRef Biogrid Interaction:
COPS5
—
CDKN1B
(physical association, affinity chromatography technology)
Kouvaraki et al., Cancer Res 2006*
-
IRef Hprd Interaction:
COPS5
—
CDKN1B
(in vivo)
Yang et al., Oncogene 2005*
-
IRef Intact Interaction:
COPS5
—
CDKN1B
(colocalization, fluorescence microscopy)
Caballero et al., Oncogene 2002*
-
IRef Intact Interaction:
COPS5
—
CDKN1B
(physical association, anti bait coimmunoprecipitation)
Caballero et al., Oncogene 2002*
-
IRef Intact Interaction:
Complex of CDKN1B-COPS5-TXN
(association, pull down)
Hwang et al., Oncogene 2004*
Text-mined interactions from Literome
Kouvaraki et al., Cancer Res 2003
(Breast Neoplasms...) :
The
Jun activation domain binding protein 1 ( JAB1 ), aside from being an activator protein 1 coactivator, is
involved in degradation of the
cyclin dependent kinase inhibitor p27
Hsieh et al., Mol Cancer Res 2007
(Carcinoma, Hepatocellular...) :
Hepatitis B virus pre-S2 mutant surface antigen
induces degradation of
cyclin dependent kinase inhibitor p27Kip1 through
c-Jun activation domain binding protein 1
Gao et al., Med Oncol 2012
(Carcinoma, Squamous Cell...) :
The
Jun activation domain binding protein 1 ( Jab1 ) may be
involved in degradation of the
cyclin dependent kinase inhibitor p27 , but it has not been clarified