Gene interactions and pathways from curated databases and text-mining

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CDKN1B — COPS5

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: CDKN1B → COPS5 (decreases) Hwang et al., Oncogene 2004*
    Evidence: Jab1 was also identified as a direct negative regulator of the CDK inhibitor, p27Kip1, resulting in cell cycle progression (Tomoda et al., 1999).
  • OpenBEL Selventa BEL large corpus: CDKN1B → COPS5 (decreases) Hwang et al., Oncogene 2004*
    Evidence: Jun activation domain-binding protein 1 (Jab1) was originally identified as a coactivator of activator protein 1 (AP1) transcription and was also shown to promote degradation of the cyclin-dependent kinase inhibitor, p27Kip1.

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Kouvaraki et al., Cancer Res 2003 (Breast Neoplasms...) : The Jun activation domain binding protein 1 ( JAB1 ), aside from being an activator protein 1 coactivator, is involved in degradation of the cyclin dependent kinase inhibitor p27
Hsieh et al., Mol Cancer Res 2007 (Carcinoma, Hepatocellular...) : Hepatitis B virus pre-S2 mutant surface antigen induces degradation of cyclin dependent kinase inhibitor p27Kip1 through c-Jun activation domain binding protein 1
Gao et al., Med Oncol 2012 (Carcinoma, Squamous Cell...) : The Jun activation domain binding protein 1 ( Jab1 ) may be involved in degradation of the cyclin dependent kinase inhibitor p27 , but it has not been clarified