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CRK — FOXO1
Text-mined interactions from Literome
Naïmi et al., Endocrinology 2007
(MAP Kinase Signaling System) :
In contrast,
Foxo1-ADA increases p38 activity, and
p38 is
required for effects of Foxo1 on PKB, at least in part
Taniguchi Ishikawa et al., Proc Natl Acad Sci U S A 2012
:
Cell cycle quiescence is associated with down-regulation of cyclin D1, up-regulation of the cyclin dependent kinase inhibitors, p21 ( cip1. ) and p16(INK4a), and Forkhead transcriptional factor 1 (
Foxo1 ), and
activation of
p38 mitogen activated protein kinase ( MAPK ), indicating that H-Cx43-deficient HSCs are prone to senescence