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CSF2 — RELA

Pathways - manually collected, often from reviews:

• WikiPathways Photodynamic therapy-induced NF-kB survival signaling: NFKB1/RELA/REL/NFKB2/RELB → IL1A/IL1B/IL2/IL6/CXCL8/CSF2/TNF/PTGS2/ICAM1/VCAM1/CXCL2/CD40LG/SELE (activation)
  

Text-mined interactions from Literome

Isaacs et al., J Cell Physiol 1999 : Role of NFkappaB in the regulation of macrophage colony stimulating factor by tumor necrosis factor-alpha in ST2 bone stromal cells
Seppänen et al., Oncol Res 1998 (Adenocarcinoma...) : In the present study, we have investigated the effects of interferons-alpha (IFN-alpha) and -gamma ( IFN-gamma ), interleukin-10 (IL-10) and -13 ( IL-13 ), transforming growth factor-beta1 ( TGF-beta1 ), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and tumor necrosis factor-alpha (TNF-alpha) on cell proliferation and induction of transcription factors AP-1 and NF-kappaB in UM-EC-3 human endometrial adenocarcinoma cells and UT-OC-5 ovarian carcinoma cells in vitro
Heyninck et al., J Cell Biol 1999 : We show that A20 does not inhibit TNF- induced nuclear translocation and DNA binding of NF-kappaB, although it completely prevents the TNF- induced activation of an NF-kappaB dependent reporter gene, as well as TNF induced IL-6 and granulocyte macrophage-colony stimulating factor gene expression
Kim et al., J Immunol 2000 : Thus, HRV-16 induces epithelial expression of IL-8 and IL-6 by an NF-kappaB independent pathway, whereas induction of GM-CSF is at least partially dependent upon NF-kappaB activation
Rogler et al., Scand J Gastroenterol 2001 (Colitis, Ulcerative...) : The induction of IL-8, M-CSF and GM-CSF , but not of IL-6 secretion, is mediated mainly by NF-kappaB activation
Kamthong et al., Biochem J 2001 : We have recently reported that interleukin-1alpha (IL-1alpha) can induce human macrophage colony stimulating factor ( M-CSF ) expression through nuclear factor kappaB (NF-kappaB) activation, and treatment of human pancreatic MIA PaCa-2 cancer cells with forskolin or cAMP attenuated the NF-kappaB activation as well as M-CSF expression
Crane et al., Cell Immunol 2001 (Calcium Signaling) : IL-1beta stimulated GM-CSF mRNA expression and production was strongly dependent on NF-kappaB
Greiber et al., J Am Soc Nephrol 2002 : Activation of the transcription factor nuclear factor-kappaB (NF-kappaB) but not activator protein-1 was involved in the upregulation of ROS induced GM-CSF production
Palanki et al., Curr Med Chem 2002 (Autoimmune Diseases) : In activated T cells, transcription factors such as the activator protein-1 (AP-1) regulate IL-2 production and production of matrix metalloproteinases, the nuclear factor kappa B (NF-kappa B) is essential for the transcriptional regulation of the proinflammatory cytokines IL-1, IL-6, IL-8 and TNF alpha, and nuclear factor of activated T-cells ( NFAT ) is required for the transcriptional regulation of IL-2, IL-3, IL-4, IL-5, IL-8, IL-13, TNF alpha, and GM-CSF
Raychaudhuri et al., Clin Immunol 2002 (Hypertension, Pulmonary) : However, mRNA expression was decreased compared to controls for NF-kappaB regulated genes, granulocyte macrophage colony stimulating factor , interleukin-6, macrophage inflammatory protein-1alpha ( MIP-1alpha ), and vascular endothelial growth factor
Wong et al., Am J Respir Cell Mol Biol 2003 : IL-3, IL-5, and GM-CSF could enhance p38 MAPK and NF-kappaB activity and induce ICAM-1, CD11b, and CD18 expressions on eosinophils
Ebner et al., Blood 2003 : GMCSF activates NF-kappaB via direct interaction of the GMCSF receptor with IkappaB kinase beta ... Functional studies demonstrated GMCSF dependent activation of IkappaB kinase activity in endothelial cells, degradation of IkappaB, and activation of NF-kappaB
Choi et al., Blood 2003 : LPS, but not GM-CSF or DEX, activated NF-kappaB as shown by IkappaBalpha degradation, NF-kappaB DNA binding, and transcriptional activity
Vital et al., Mediators Inflamm 2003 : GM-CSF induced iNOS expression and NO production, and activated the transcription factor NF-kappaB ... Dexamethasone also inhibited GM-CSF induced NF-kappaB activation by preventing a significant decrease on the IkappaB-alpha protein levels, thus blocking NF-kappaB migration to the nucleus ... The corticosteroid dexamethasone inhibits GM-CSF induced NF-kappaB activation, iNOS protein expression and NO production
Koch et al., Am J Respir Cell Mol Biol 2004 : SN50 ( 100 microM ), an inhibitor of NF-kappaB translocation and the specific IKK-2-Inhibitor ( AS602868 ; 10 microM ), also prevented GM-CSF expression and release induced by LPS, indicating that GM-CSF release is NF-kappaB dependent ... GM-CSF expression and release in AM is controlled by NF-kappaB activation, and this is modulated by phosphorylation of MKK-1 and p38 MAP kinase acting on histone acetylation
Gagliardo et al., Am J Respir Crit Care Med 2003 (Asthma) : Freed NF-kappaB then induces expression of cytokines such as granulocyte-macrophage colony stimulating factor , interleukin-8, and regulated upon activation, normal T cell expressed and secreted
Birkenkamp et al., Leukemia 2004 (Acute Disease...) : The constitutive NF-kappaB activity could so far not be ascribed to the autocrine production of growth factors or to mutations in the Flt3 receptor, since anti-GM-CSF , -IL-1, -IL6, -TNFalpha or the tyrosine kinase inhibitor AG1296 did not affect the NF-kappaB DNA binding activity
Kettritz et al., J Biol Chem 2004 : GM-CSF and IL-8 did not activate NF-kappaB in suspended neutrophils but rapidly activated NF-kappaB under adherent conditions on matrix, as shown by IkappaB kinase activity assay, IkappaBalpha degradation, electromobility shift assay, and quantitative reverse transcriptase-PCR ... Specific beta ( 2 ) integrin blockade prevented NF-kappaB activation by GM-CSF and IL-8 on fibronectin ... Co-stimulating CD18 and CD11b with activating antibodies resulted in NF-kappaB activation by GM-CSF and IL-8 in suspended cells
Ono et al., Shock 2004 (Hepatitis, Alcoholic...) : We previously demonstrated that production of interleukin-6 (IL-6) and granulocyte colony stimulating factor ( G-CSF ), mediated by nuclear factor-kappa B (NF-kappa B) , each make essential contributions to organ injury and inflammation in a rodent model of controlled HS, and we proposed in this study to examine the hypothesis that the increased susceptibility to MOF after shock/trauma in the setting of chronic ethanol use is due to an exaggerated activation of NF-kappa B and production of these proinflammatory cytokines
Coward et al., Clin Exp Allergy 2004 : The NF-kappaB inhibitors, calpain inhibitor 1 ( 10 microm ), pentoxifylline ( 0.5 mm ), pyrrolidine dithiocarbamate ( PDTC, 10 microm ) or gliotoxin ( 1 pg/mL ) reduced the generation of GM-CSF , TNF-alpha and IL-8 in parallel with their inhibition of NF-kappaB
Shephard et al., Thromb Haemost 2004 : GM-CSF activated NFkappaB , thus interfering with TGF-beta signaling
Oster et al., Blood 1992 : However, the action of IL-3 on synthesis of IL-1 beta mRNA differs from that of other CSFs : While GM-CSF and M-CSF induce binding activity of the nuclear factor (NF) kappa B , IL-3 treatment of MNP has no profound effect on NF kappa B binding to DNA
Nardelli et al., Endocrinology 2006 : Osteostat suppresses the early stage of osteoclastogenesis via inhibition of macrophage colony stimulating factor induced receptor activator of NF-kappaB ( RANK ) expression in the osteoclast precursor cells
Lendemans et al., J Endotoxin Res 2006 : In contrast, the broad-spectrum tyrosine kinase inhibitor genistein and the MEK-1 inhibitor ( PD98059 ) abrogated GM-CSF priming of TNF-alpha release and activation of both NF-kappaB and AP-1
Zaheer et al., J Neurochem 2007 (Encephalitis...) : Inhibition of p38 MAPK or NF-kappaB by specific inhibitors prevented GM-CSF production
Martinez-Losa et al., Eur Respir J 2007 : The increase in eosinophil NF-kappaB binding activity induced by GM-CSF and TNF-alpha was suppressed by NAC
Lu et al., Mol Immunol 2008 : It thus activates downstream signaling events to activate transcription factor NF-kappaB , and induce the expression of IL-1 responsive genes such as TNF-alpha and GM-CSF
Scicchitano et al., Blood Cells Mol Dis 2008 (MAP Kinase Signaling System) : In addition, these results suggest that IL-6, IL-11, GM-CSF , G-CSF and Activin A are similarly regulated by p38 and NF-kappaB and that the MEK1, JNK and PKC pathways appear to play a more limited role in modulating cytokine expression in HBMSC
Martinez-Losa et al., Clin Exp Allergy 2009 : The activation of eosinophil NF-kappaB induced by GM-CSF and IL-5 was suppressed by TauCl
Szczepanski et al., Cancer Res 2009 (Carcinoma, Squamous Cell...) : LPS binding to TLR4 on tumor cells enhanced proliferation, activated phosphatidylinositol 3-kinase/Akt pathway, up-regulated IRAK-4 expression, induced nuclear NF-kappaB translocation, and increased production ( P < 0.05 ) of interleukin (IL)-6, IL-8, vascular endothelial growth factor, and granulocyte macrophage colony stimulating factor
Li et al., J Dent Res 2009 : NF-kappaB activation was noted during interaction of epithelial cells with C. glabrata, and pre-treatment with an NF-kappaB inhibitor partly inhibited GM-CSF synthesis
Sasaki et al., J Biol Chem 2011 : Recruitment of RelB to the Csf2 promoter enhances RelA mediated transcription of granulocyte-macrophage colony stimulating factor
Himes et al., Oncogene 1993 : HTLV-1 tax activation of the GM-CSF and G-CSF promoters requires the interaction of NF-kB with other transcription factor families
Brach et al., J Immunol 1993 : Transcriptional activation of the macrophage colony stimulating factor gene by IL-2 is associated with secretion of bioactive macrophage colony stimulating factor protein by monocytes and involves activation of the transcription factor NF-kappa B
Grammer et al., J Immunol 1998 (Burkitt Lymphoma) : By contrast, induction of apoptosis, activation of NF-kappaB , generation of granulocyte-macrophage CSF , and up-regulation of CD54, MHC class II, and CD95 were unaffected by the TRAF3 dominant negative