Gene interactions and pathways from curated databases and text-mining

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CSN3 — SKP1

Text-mined interactions from Literome

Cope et al., Cell 2003 : Here, we summarize what is known about CSN, and discuss hypotheses for how CSN promotes the activity of SCF ubiquitin ligases
Carrabino et al., Brain Res Gene Expr Patterns 2004 : The CSN controls the function of the SCF ubiquitin-ligase complex through an enzymatic activity that removes the small ubiquitin-like molecule NEDD8 from the cullin component of the SCF and that requires subunit 5 of the CSN ( JAB1/CSN5 )
Enchev et al., Cell reports 2012 : Taken together, the results provide a model for how reciprocal regulation sensitizes CSN to the SCF assembly state and inhibits a catalytically competent SCF until a ubiquitination substrate drives its own degradation by displacing CSN, thereby promoting cullin neddylation and substrate ubiquitination
Huang et al., PloS one 2013 : Unexpectedly however, csn3-3 plants are not defective in either the CSN mediated deneddylation of CUL1 or in SCF ( TIR1 ) -mediated degradation of Aux/IAA proteins