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CXCL3 — TNF
Text-mined interactions from Literome
Cheng et al., J Immunol 2002
:
We found that incubation of human dermal microvascular endothelial cells with recombinant eotaxin/CCL11 suppresses
TNF-alpha induced production of the neutrophil-specific chemokine
IL-8/CXCL8
Hardaker et al., FASEB J 2004
(Inflammation...) :
In primary cultured hASM cells taken from normal donors,
CXCL10 protein expression was
induced by IFN-gamma and
TNF-alpha , cytokines reported as elevated in COPD, and a synergistic response was obtained when they were combined
Juarranz et al., Rheumatology (Oxford) 2004
(Arthritis, Rheumatoid...) :
The effects of VIP on basal or
tumour necrosis factor alpha (TNF-alpha) stimulated production of CCL2 ( MCP-1, monocyte chemotactic protein 1 ),
CXCL8 [ interleukin (IL)-8 ], IL-6 and TNF-alpha were studied by specific ELISAs ( enzyme linked immunosorbent assays )
Green et al., J Infect Dis 2006
:
Analysis of > 1500 ARE containing cellular mRNAs, by use of microarrays, revealed that
CXCL-8 and other newly identified ARE genes were
induced by
TNF- alpha in Huh7 cells and were coordinately regulated
De Plaen et al., Immunology 2006
:
In conclusion,
CXCL2 gene is expressed in enterocytes in
response to both
TNF and LPS
Kamohara et al., Int J Oncol 2007
(Inflammation...) :
Induction of interleukin-8 (
CXCL-8 ) by
tumor necrosis factor-alpha and leukemia inhibitory factor in pancreatic carcinoma cells : Impact of CXCL-8 as an autocrine growth factor
Funakoshi-Tago et al., Biochem Pharmacol 2008
:
As a result,
TNFalpha induced expression of inflammatory cytokines,
CXCL1/KC and CCL2/MCP-1, was clearly inhibited by Celecoxib
Lee et al., J Immunol 2008
:
IL-17 strongly repressed TNF-alpha stimulated expression of CXCL10, CXCL11, and CCL5, but
synergized with
TNF-alpha for induction of
CXCL8 , CXCL1, and CCL20 mRNAs
Funakoshi-Tago et al., Cytokine 2009
:
Interestingly, we observed that
TNFalpha induced expression of IL-6,
CXCL1 and granulocyte macrophage colony stimulating factor ( GM-CSF ) were significantly enhanced in TRAF6-deficient MEFs
Subileau et al., J Neuropathol Exp Neurol 2009
(Inflammation...) :
Tumor necrosis factor strongly
increased the production of CCL2, CCL5, and
CXCL8 ; interferon gamma upregulated CXCL10 exclusively
Heuvelin et al., PloS one 2009
(Colitis) :
TNFalpha induced chemokine (
CXCL8 ) secretion and alteration of NF-kappaB and AP-1 signalling pathways by Bb were studied by EMSA, confocal microscopy and western blotting
John et al., J Immunol 2009
(Asthma) :
Furthermore, chromatin immunoprecipitation studies detected increased binding of NF-kappaB p65 and RNA polymerase II to the
CXCL8 promoter of asthmatic HASM cells both in the
presence and absence of
TNF-alpha stimulation
Földes et al., PloS one 2010
:
Expression of downstream TLR signalling pathways was demonstrated in hESC, and IL-1beta,
TNFalpha and INFgamma, which bypass the TLRs,
stimulated CXCL8 release
Stich et al., Res Vet Sci 2011
:
Lipopolysaccharide was a more potent inducer of IL-1ß and
CXCL-8 than LTA or PG and LTA is a more potent inducer of CXCL-8 than PG. Based on these data, PAMPs from gram positive and negative bacteria
induce TNF , IL-1ß and CXCL-8 production in feline whole blood
Robins et al., Am J Respir Cell Mol Biol 2011
(Asthma...) :
In contrast to epithelial and endothelial cells,
TNF-a stimulated
CXCL8 synthesis was dependent on ERK1/ERK2 but not on p38 MAPK
Kanda et al., Endocrinology 2011
(Psoriasis) :
Visfatin enhanced
TNF-a induced
CXC chemokine ligand ( CXCL ) 8, CXCL10, and CC chemokine ligand (CCL) 20 secretion and mRNA expression in keratinocytes, although visfatin alone was ineffective
Chang et al., J Allergy Clin Immunol 2012
(Asthma) :
In patients with severe asthma, dexamethasone caused less suppression of CCL11 and
CXCL8 release
induced by
TNF-a
Xu et al., Pharmacol Res 2013
:
TNF-a induced
CXCL8 production by A549 cells : Involvement of the non-neuronal cholinergic system ... In A549 cells,
TNF-a increased the release of
CXCL8 and ACh and the expression of the subtype 3 MR ( M3R ) ... Furthermore,
TNF-a induced
CXCL8 secretion was ( i ) inhibited by the MR antagonist tiotropium and the M3R antagonist 4-DAMP and ( ii ) enhanced by the M1/M3R agonist pilocarpine and the cholinesterase inhibitor physostigmine ... Taken as a whole, these results suggest that ACh release by A549 cells enhances
TNF-a induced
CXCL8 secretion through activation of the M3R ... Our results suggest that the
TNF-a induced secretion of
CXCL8 in A549 cells is regulated by the release of ACh, the latter 's binding to the M3R and the downstream activation of NF-?B and the ERK1/2 and p38 MAPK signaling pathways
Xu et al., J Immunol 2013
(Psoriasis) :
Specific inhibition of miR-31 suppressed NF-?B-driven promoter luciferase activity and the basal and
TNF-a induced production of IL-1ß, CXCL1/growth related oncogene-a, CXCL5/epithelial derived neutrophil activating peptide 78, and
CXCL8/IL-8 in human primary keratinocytes
Kobayashi et al., Br J Pharmacol 2013
:
Corticosteroid sensitivity was determined by IC50 /EC50 of dexamethasone ( Dex ) on
TNF-a induced
CXCL8 production in U937 monocytic cell line and peripheral blood mononuclear cells ( PBMC ) from COPD patients
Son et al., Journal of inflammation (London, England) 2013
:
Finally, CCL20 and
CXCL8 responded synergistically in
response to EGF and
TNF in OVCAR-3 and SKOV-3 cells