Gene interactions and pathways from curated databases and text-mining

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CXCL3 — TNF

Text-mined interactions from Literome

Cheng et al., J Immunol 2002 : We found that incubation of human dermal microvascular endothelial cells with recombinant eotaxin/CCL11 suppresses TNF-alpha induced production of the neutrophil-specific chemokine IL-8/CXCL8
Hardaker et al., FASEB J 2004 (Inflammation...) : In primary cultured hASM cells taken from normal donors, CXCL10 protein expression was induced by IFN-gamma and TNF-alpha , cytokines reported as elevated in COPD, and a synergistic response was obtained when they were combined
Juarranz et al., Rheumatology (Oxford) 2004 (Arthritis, Rheumatoid...) : The effects of VIP on basal or tumour necrosis factor alpha (TNF-alpha) stimulated production of CCL2 ( MCP-1, monocyte chemotactic protein 1 ), CXCL8 [ interleukin (IL)-8 ], IL-6 and TNF-alpha were studied by specific ELISAs ( enzyme linked immunosorbent assays )
Green et al., J Infect Dis 2006 : Analysis of > 1500 ARE containing cellular mRNAs, by use of microarrays, revealed that CXCL-8 and other newly identified ARE genes were induced by TNF- alpha in Huh7 cells and were coordinately regulated
De Plaen et al., Immunology 2006 : In conclusion, CXCL2 gene is expressed in enterocytes in response to both TNF and LPS
Kamohara et al., Int J Oncol 2007 (Inflammation...) : Induction of interleukin-8 ( CXCL-8 ) by tumor necrosis factor-alpha and leukemia inhibitory factor in pancreatic carcinoma cells : Impact of CXCL-8 as an autocrine growth factor
Funakoshi-Tago et al., Biochem Pharmacol 2008 : As a result, TNFalpha induced expression of inflammatory cytokines, CXCL1/KC and CCL2/MCP-1, was clearly inhibited by Celecoxib
Lee et al., J Immunol 2008 : IL-17 strongly repressed TNF-alpha stimulated expression of CXCL10, CXCL11, and CCL5, but synergized with TNF-alpha for induction of CXCL8 , CXCL1, and CCL20 mRNAs
Funakoshi-Tago et al., Cytokine 2009 : Interestingly, we observed that TNFalpha induced expression of IL-6, CXCL1 and granulocyte macrophage colony stimulating factor ( GM-CSF ) were significantly enhanced in TRAF6-deficient MEFs
Subileau et al., J Neuropathol Exp Neurol 2009 (Inflammation...) : Tumor necrosis factor strongly increased the production of CCL2, CCL5, and CXCL8 ; interferon gamma upregulated CXCL10 exclusively
Heuvelin et al., PloS one 2009 (Colitis) : TNFalpha induced chemokine ( CXCL8 ) secretion and alteration of NF-kappaB and AP-1 signalling pathways by Bb were studied by EMSA, confocal microscopy and western blotting
John et al., J Immunol 2009 (Asthma) : Furthermore, chromatin immunoprecipitation studies detected increased binding of NF-kappaB p65 and RNA polymerase II to the CXCL8 promoter of asthmatic HASM cells both in the presence and absence of TNF-alpha stimulation
Földes et al., PloS one 2010 : Expression of downstream TLR signalling pathways was demonstrated in hESC, and IL-1beta, TNFalpha and INFgamma, which bypass the TLRs, stimulated CXCL8 release
Stich et al., Res Vet Sci 2011 : Lipopolysaccharide was a more potent inducer of IL-1ß and CXCL-8 than LTA or PG and LTA is a more potent inducer of CXCL-8 than PG. Based on these data, PAMPs from gram positive and negative bacteria induce TNF , IL-1ß and CXCL-8 production in feline whole blood
Robins et al., Am J Respir Cell Mol Biol 2011 (Asthma...) : In contrast to epithelial and endothelial cells, TNF-a stimulated CXCL8 synthesis was dependent on ERK1/ERK2 but not on p38 MAPK
Kanda et al., Endocrinology 2011 (Psoriasis) : Visfatin enhanced TNF-a induced CXC chemokine ligand ( CXCL ) 8, CXCL10, and CC chemokine ligand (CCL) 20 secretion and mRNA expression in keratinocytes, although visfatin alone was ineffective
Chang et al., J Allergy Clin Immunol 2012 (Asthma) : In patients with severe asthma, dexamethasone caused less suppression of CCL11 and CXCL8 release induced by TNF-a
Xu et al., Pharmacol Res 2013 : TNF-a induced CXCL8 production by A549 cells : Involvement of the non-neuronal cholinergic system ... In A549 cells, TNF-a increased the release of CXCL8 and ACh and the expression of the subtype 3 MR ( M3R ) ... Furthermore, TNF-a induced CXCL8 secretion was ( i ) inhibited by the MR antagonist tiotropium and the M3R antagonist 4-DAMP and ( ii ) enhanced by the M1/M3R agonist pilocarpine and the cholinesterase inhibitor physostigmine ... Taken as a whole, these results suggest that ACh release by A549 cells enhances TNF-a induced CXCL8 secretion through activation of the M3R ... Our results suggest that the TNF-a induced secretion of CXCL8 in A549 cells is regulated by the release of ACh, the latter 's binding to the M3R and the downstream activation of NF-?B and the ERK1/2 and p38 MAPK signaling pathways
Xu et al., J Immunol 2013 (Psoriasis) : Specific inhibition of miR-31 suppressed NF-?B-driven promoter luciferase activity and the basal and TNF-a induced production of IL-1ß, CXCL1/growth related oncogene-a, CXCL5/epithelial derived neutrophil activating peptide 78, and CXCL8/IL-8 in human primary keratinocytes
Kobayashi et al., Br J Pharmacol 2013 : Corticosteroid sensitivity was determined by IC50 /EC50 of dexamethasone ( Dex ) on TNF-a induced CXCL8 production in U937 monocytic cell line and peripheral blood mononuclear cells ( PBMC ) from COPD patients
Son et al., Journal of inflammation (London, England) 2013 : Finally, CCL20 and CXCL8 responded synergistically in response to EGF and TNF in OVCAR-3 and SKOV-3 cells